Cerebellar contributions to visuomotor adaptation and motor sequence learning: an ALE meta-analysis.
Cerebellar contributions to visuomotor adaptation and motor sequence learning: an ALE meta-analysis.
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DOI：
10.3389/fnhum.2013.00027
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发表时间：
2013
影响因子：
2.9
通讯作者：
Seidler RD
中科院分区：
文献类型：
--
作者：
Bernard JA;Seidler RD
小脑对运动学习的贡献已有充分的记录。例如，在某些情况下，小脑损伤的患者在视觉适应和获得新的动作序列方面受到损害。此外，在各种运动学习任务的功能性MRI（fMRI）研究中观察到小脑激活。运动学习的早期阶段对认知要求很高，依赖于工作记忆等过程，这些过程也与小脑有关。在这里，我们研究小脑的贡献，运动学习使用激活似然估计（ALE）荟萃分析。这使我们能够确定，在不同的研究和任务中，小脑激活的位置是否在不同的运动学习任务中是恒定的，以及小脑在早期学习中的激活是否与工作记忆中观察到的重叠。我们发现小脑前部的不同区域参与内隐和外显序列学习和视觉适应，为小脑功能的模块化提供了额外的证据。此外，我们发现，小叶VI的小脑，这已经牵连到工作记忆，被激活在早期阶段的外显运动序列学习。这为小脑在与运动学习相关的认知过程中的潜在作用提供了证据。然而，尽管小叶VI在早期外显序列学习和工作记忆研究中都被激活，但这两个区域之间没有空间重叠。总之，我们的研究结果支持模块化的想法，在形成新的运动任务在小脑的内部表示，并强调在运动技能学习的早期阶段所依赖的认知处理。
Cerebellar contributions to motor learning are well-documented. For example, under some conditions, patients with cerebellar damage are impaired at visuomotor adaptation and at acquiring new action sequences. Moreover, cerebellar activation has been observed in functional MRI (fMRI) investigations of various motor learning tasks. The early phases of motor learning are cognitively demanding, relying on processes such as working memory, which have been linked to the cerebellum as well. Here, we investigated cerebellar contributions to motor learning using activation likelihood estimation (ALE) meta-analysis. This allowed us to determine, across studies and tasks, whether or not the location of cerebellar activation is constant across differing motor learning tasks, and whether or not cerebellar activation in early learning overlaps with that observed for working memory. We found that different regions of the anterior cerebellum are engaged for implicit and explicit sequence learning and visuomotor adaptation, providing additional evidence for the modularity of cerebellar function. Furthermore, we found that lobule VI of the cerebellum, which has been implicated in working memory, is activated during the early stages of explicit motor sequence learning. This provides evidence for a potential role for the cerebellum in the cognitive processing associated with motor learning. However, though lobule VI was activated across both early explicit sequence learning and working memory studies, there was no spatial overlap between these two regions. Together, our results support the idea of modularity in the formation of internal representations of new motor tasks in the cerebellum, and highlight the cognitive processing relied upon during the early phases of motor skill learning.
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DOI：
10.1016/j.cogbrainres.2004.06.014
发表时间：
2004-11-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
2011-07-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
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通讯作者：
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