Systemic Glycemic Variation Predicts Mortality of Acute Ischemic Stroke After Mechanical Thrombectomy: A Prospective Study Using Continuous Glucose Monitoring.
Systemic Glycemic Variation Predicts Mortality of Acute Ischemic Stroke After Mechanical Thrombectomy: A Prospective Study Using Continuous Glucose Monitoring.
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DOI：
10.3389/fneur.2022.817033
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发表时间：
2022
影响因子：
3.4
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Deng J;Li L;Cao F;Wang F;Wang H;Shi H;Shen L;Zhao F;Zhao Y
我们研究了机械血栓切除术（MT）后血糖变化与大血管闭塞（LVO）诱导的急性缺血性卒中（AIS）临床结局的相关性。我们招募了连续的缺血性卒中患者。在70例接受MT的AIS患者中，通过动态血糖监测评估血糖水平。包括血糖水平高于范围的时间百分比、低血糖范围和范围内的时间、变异系数、标准差（SD）、每日差异的平均值、血糖波动的平均幅度、血糖波动的最大幅度、高血糖指数和低血糖指数。这项观察性研究的结局是住院死亡率、住院期间神经功能改善、功能独立性和随访（3个月）时的死亡率。分析血糖指标与结局的相关性。平均监测时间为3.5 d，平均每人监测血糖728次。在校正潜在混杂因素后，以SD表示的血糖变化与院内死亡率[比值比（OR）：2.8，95%置信区间（CI）：1.276-6.145，p = 0.01]和3个月死亡率（OR：2.107，95% CI：1.013-4.382，p = 0.046）独立相关。血糖变化与3个月的临床功能独立性无关。全身血糖变异增加与MT后LVO-AIS死亡率升高相关。http://www.chictr.org.cn/showproj.aspx? proj=21016，标识符：ChiCTR-OOC-17012378。
We investigated the association of glycemic variation with the clinical outcomes of large vessel occlusion (LVO) induced acute ischemic stroke (AIS) after mechanical thrombectomy (MT). We recruited consecutive ischemic patients with stroke. Glucose levels were assessed through continuous glucose monitoring in 70 patients with AIS who had undergone MT. Metrics including percentages of time of glucose levels above the range, the hypoglycemic range, and the time within the range, coefficient of variation, standard deviation (SD), mean of daily differences, mean amplitude of glycemic excursion, largest amplitude of glycemic excursion, high blood glucose index, and low blood glucose index. The outcomes of this observational study were in-hospital mortality, neurological improvement during hospitalization, functional independence, and mortality at follow-up (3 months). The associations of the blood glucose metrics with outcomes were analyzed. The average period of glucose monitoring was 3.5 days, and serum glucose was recorded 728 times after MT for each person. The glycemic variation expressed in SDs was independently associated with in-hospital mortality [odds ratio (OR): 2.8, 95% confidence interval (CI): 1.276–6.145, p = 0.01] and the 3-month mortality (OR: 2.107, 95% CI: 1.013–4.382, p = 0.046) after adjusting for potential confounders. There was no association of glycemic variation with the 3-month clinical functional independence. Increased systemic glycemic variation was associated with higher odds of mortality of LVO-AIS after MT. http://www.chictr.org.cn/showproj.aspx?proj=21016, identifier: ChiCTR-OOC-17012378.
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影响因子：
3.8
作者：
Ma H;Yu G;Wang Z;Zhou P;Lv W
通讯作者：
Lv W
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