The Pneumonia Etiology Research for Child Health Project: a 21st century childhood pneumonia etiology study.
The Pneumonia Etiology Research for Child Health Project: a 21st century childhood pneumonia etiology study.
复制标题
DOI：
10.1093/cid/cir1052
复制
发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Scott JA
中科院分区：
文献类型：
--
作者：
Levine OS;O'Brien KL;Deloria-Knoll M;Murdoch DR;Feikin DR;DeLuca AN;Driscoll AJ;Baggett HC;Brooks WA;Howie SR;Kotloff KL;Madhi SA;Maloney SA;Sow S;Thea DM;Scott JA
儿童健康肺炎病因学研究 (PERCH) 项目是一项涉及 7 个国家的标准化综合评估，旨在对发展中国家儿童中引起严重肺炎的病因进行评估。在之前的病因学研究中，四分之一到三分之一的患者未能得出明显的病因； PERCH 将采用和评估以前无法使用的创新、更灵敏的诊断技术。将使用创新且严格的流行病学和分析方法来确定潜在病原体的存在与肺炎之间的因果关系。通过战略性地选择广泛代表儿童肺炎负担最重地区的研究地点，PERCH 旨在提供反映发展中国家 2015 年使用肺炎球菌和 B 型流感嗜血杆菌疫苗的流行病学情况的数据。 PERCH 还将解决可能决定肺炎病因的宿主、环境和/或地理因素的差异，并通过保存标本为未来的研究和病原体发现提供资源。
The Pneumonia Etiology Research for Child Health (PERCH) project is a 7-country, standardized, comprehensive evaluation of the etiologic agents causing severe pneumonia in children from developing countries. During previous etiology studies, between one-quarter and one-third of patients failed to yield an obvious etiology; PERCH will employ and evaluate previously unavailable innovative, more sensitive diagnostic techniques. Innovative and rigorous epidemiologic and analytic methods will be used to establish the causal association between presence of potential pathogens and pneumonia. By strategic selection of study sites that are broadly representative of regions with the greatest burden of childhood pneumonia, PERCH aims to provide data that reflect the epidemiologic situation in developing countries in 2015, using pneumococcal and Haemophilus influenzae type b vaccines. PERCH will also address differences in host, environmental, and/or geographic factors that might determine pneumonia etiology and, by preserving specimens, will generate a resource for future research and pathogen discovery.
登录
查看更多内容
影响因子：
158.5
作者：
Klugman, KP;Madhi, SA;Pierce, N
通讯作者：
Pierce, N
影响因子：
168.9
作者：
Bryce, Jennifer;Daelmans, Bernadette;Wardlaw, Tessa
通讯作者：
Wardlaw, Tessa
影响因子：
3.7
作者：
Fry, Alicia M.;Lu, Xiaoyan;Erdman, Dean
通讯作者：
Erdman, Dean
影响因子：
3.6
作者：
Levine, OS;Lagos, R;Levine, MM
通讯作者：
Levine, MM
影响因子：
168.9
作者：
Cutts, FT;Zaman, SMA;Adegbola, RA
通讯作者：
Adegbola, RA