Presence and dynamics of leptin, GLP-1, and PYY in human breast milk at early postpartum.
Presence and dynamics of leptin, GLP-1, and PYY in human breast milk at early postpartum.
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DOI：
10.1002/oby.20345
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发表时间：
2013-07
期刊：
影响因子：
6.9
通讯作者：
Larson-Meyer, D. Enette
中科院分区：
文献类型：
--
作者：
Schueler, Jessica;Alexander, Brenda;Hart, Ann Marie;Austin, Kathleen;Larson-Meyer, D. Enette
目的：母乳中存在食欲激素，即胰高血糖素样肽-1（GLP-1）、肽YY（PYY）和瘦素，可能在婴儿喂养调节和婴儿生长中起重要作用。 本研究评估了GLP-1、PYY和瘦素的浓度是否在单次喂养（从前乳到后乳）中发生变化，并与产妇和婴儿的人体测量学相关。设计和方法：13名产后妇女（平均值± SD：25.6 ± 4.5岁，72.0 ± 11.9 kg）在分娩后4-5周提供了前乳和后乳样本，并通过双X射线吸收法测量了体重和成分。 GLP-1，PYY，瘦素浓度测定采用放射免疫法，乳脂含量测定采用creamatocrit。结果：后乳中GLP-1含量和乳脂含量均高于前乳（P ≤ 0.05）。 PYY和瘦素浓度没有改变前和后乳。瘦素水平和乳脂含量均与母亲肥胖指数相关（r = 0.65-0.85，P < 0.02），与脂肪含量相关（r = 0.65-0.84，P < 0.02）。从出生到6个月，后乳GLP-1与婴儿体重增加相关（r =-0.67，P = 0.034）。结论：母乳中食欲激素的存在可能对婴儿食欲和生长调节很重要。
Objective: The presence of appetite hormones, namely glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and leptin in breast milk may be important in infant feeding regulation and infant growth. This study evaluated whether concentrations of GLP-1, PYY, and leptin change across a single feeding (from fore- to hindmilk), and are associated with maternal and infant anthropometrics. Design and Methods: Thirteen postpartum women (mean ± SD: 25.6 ± 4.5 years, 72.0 ± 11.9 kg) provided fore- and hindmilk samples 4-5 weeks after delivery and underwent measurements of body weight and composition by Dual X-ray Absorptiometry. GLP-1, PYY, and leptin concentrations were measured using radioimmunoassay, and milk fat content was determined by creamatocrit. Results: Concentration of GLP-1 and content of milk fat was higher in hindmilk than foremilk (P ≤ 0.05). PYY and leptin concentrations did not change between fore- and hindmilk. Both leptin concentration and milk fat content were correlated with indices of maternal adiposity, including body mass index (r = 0.65-0.85, P < 0.02), and fat mass (r = 0.65-0.84, P < 0.02). Hindmilk GLP-1 was correlated with infant weight gain from birth to 6 months (r = −0.67, P = 0.034). Conclusion: The presence of appetite hormones in breast milk may be important in infant appetite and growth regulation.
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影响因子：
4.8
作者：
Ruettimann, Elisabeth B.;Arnold, Myrtha;Langhans, Wolfgang
通讯作者：
Langhans, Wolfgang
影响因子：
7.1
作者：
DEWEY, KG;HEINIG, MJ;LONNERDAL, B
通讯作者：
LONNERDAL, B
DOI：
10.1097/mpg.0b013e3181977375
发表时间：
2009-03-01
影响因子：
2.9
作者：
Bouret, Sebastien G.
通讯作者：
Bouret, Sebastien G.
DOI：
10.1186/1479-5868-8-89
发表时间：
2011-08-17
期刊：
The international journal of behavioral nutrition and physical activity
影响因子：
--
作者：
Disantis KI;Collins BN;Fisher JO;Davey A
通讯作者：
Davey A
影响因子：
56.9
作者：
Bouret, SG;Draper, SJ;Simerly, RB
通讯作者：
Simerly, RB