β-Adrenergic Receptor Signaling in Prostate Cancer.
β-Adrenergic Receptor Signaling in Prostate Cancer.
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DOI：
10.3389/fonc.2014.00375
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发表时间：
2014
影响因子：
4.7
通讯作者：
Taskén KA
中科院分区：
文献类型：
--
作者：
Braadland PR;Ramberg H;Grytli HH;Taskén KA
增强的交感神经信号，通常与肥胖和慢性压力有关，越来越被认为是癌症侵袭性的一个因素。在前列腺癌中，完整的交感神经对肿瘤的形成至关重要，交感神经切除术可诱导细胞凋亡并阻断肿瘤生长。周围神经侵犯，包括前列腺内神经的富集，在前列腺癌中经常观察到，并与不良预后相关。β2-肾上腺素能受体（ADRB2）是前列腺腔细胞中最丰富的交感信号受体，已被证明可调节癌细胞向神经内分泌样细胞的反分化，并影响细胞凋亡、血管生成、上皮-间质转化、迁移和转移。流行病学研究表明，β-受体阻滞剂的使用，抑制β-肾上腺素能受体的活性，与降低前列腺癌特异性死亡率有关。在这篇综述中，我们旨在介绍β-肾上腺素能受体及其下游信号级联如何影响侵袭性前列腺癌的发展，主要是通过调节神经内分泌分化。
Enhanced sympathetic signaling, often associated with obesity and chronic stress, is increasingly acknowledged as a contributor to cancer aggressiveness. In prostate cancer, intact sympathetic nerves are critical for tumor formation, and sympathectomy induces apoptosis and blocks tumor growth. Perineural invasion, involving enrichment of intra-prostatic nerves, is frequently observed in prostate cancer and is associated with poor prognosis. β2-adrenergic receptor (ADRB2), the most abundant receptor for sympathetic signals in prostate luminal cells, has been shown to regulate trans-differentiation of cancer cells to neuroendocrine-like cells and to affect apoptosis, angiogenesis, epithelial–mesenchymal transition, migration, and metastasis. Epidemiologic studies have shown that use of β-blockers, inhibiting β-adrenergic receptor activity, is associated with reduced prostate cancer-specific mortality. In this review, we aim to present an overview on how β-adrenergic receptor and its downstream signaling cascade influence the development of aggressive prostate cancer, primarily through regulating neuroendocrine differentiation.
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影响因子：
4.9
作者：
Chamberlain, PD;Jennings, KH;Murphy, GJ
通讯作者：
Murphy, GJ
影响因子：
45.3
作者：
Barron, Thomas I.;Connolly, Roisin M.;Visvanathan, Kala
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影响因子：
8
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通讯作者：
Chiarugi, P.
影响因子：
2
作者：
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通讯作者：
Bremnes, Roy M.
影响因子：
3.6
作者：
Baker, JG;Hall, IP;Hill, SJ
通讯作者：
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