Reactive oxygen species: impact on skeletal muscle.
Reactive oxygen species: impact on skeletal muscle.
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DOI：
10.1002/cphy.c100054
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发表时间：
2011-04
影响因子：
5.8
通讯作者：
Jackson MJ
中科院分区：
文献类型：
--
作者：
Powers SK;Ji LL;Kavazis AN;Jackson MJ
众所周知，收缩的肌肉产生活性氧和活性氮。虽然运动过程中氧化剂产生的来源仍然存在争议，但越来越多的证据表明线粒体不是主要来源。无论收缩肌肉中氧化剂的来源如何，剧烈和长时间的运动都会导致收缩肌细胞中蛋白质和脂质的氧化损伤。此外，氧化剂调节许多细胞信号传导途径并调节许多基因的表达。这种氧化剂介导的基因表达变化涉及转录、mRNA稳定性和信号转导水平的变化。此外，已经鉴定了许多与氧化剂调节基因相关的产物，包括抗氧化酶、应激蛋白和线粒体电子传递蛋白。有趣的是，低水平和生理水平的活性氧是骨骼肌正常产生力所必需的，但高水平的活性氧会导致收缩功能障碍和疲劳。正在进行的研究继续探索肌肉中负责肌肉适应和氧化剂介导的肌肉疲劳的氧化还原调节的氧化还原敏感性靶点。
It is well established that contracting muscles produce both reactive oxygen and nitrogen species. Although the sources of oxidant production during exercise continue to be debated, growing evidence suggests that mitochondria are not the dominant source. Regardless of the sources of oxidants in contracting muscles, intense and prolonged exercise can result in oxidative damage to both proteins and lipids in the contracting myocytes. Further, oxidants regulate numerous cell signaling pathways and modulate the expression of many genes. This oxidant-mediated change in gene expression involves changes at transcriptional, mRNA stability, and signal transduction levels. Furthermore, numerous products associated with oxidant-modulated genes have been identified and include antioxidant enzymes, stress proteins, and mitochondrial electron transport proteins. Interestingly, low and physiological levels of reactive oxygen species are required for normal force production in skeletal muscle, but high levels of reactive oxygen species result in contractile dysfunction and fatigue. Ongoing research continues to explore the redox-sensitive targets in muscle that are responsible for both redox-regulation of muscle adaptation and oxidant-mediated muscle fatigue.
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影响因子：
5.5
作者：
Adhihetty, PJ;Ljubicic, V;Hood, DA
通讯作者：
Hood, DA
影响因子：
5.5
作者：
Andrade, FH;Reid, MB;Westerblad, H
通讯作者：
Westerblad, H
DOI：
10.1016/s1095-6433(97)00421-2
发表时间：
1998-01-01
影响因子：
2.3
作者：
Abraham, RZ;Kobzik, L;Stamler, JS
通讯作者：
Stamler, JS
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
3.3
作者：
Ameredes, BT;Provenzano, MA
通讯作者：
Provenzano, MA