Increased arthritis severity in mice coinfected with Borrelia burgdorferi and Babesia microti.
Increased arthritis severity in mice coinfected with Borrelia burgdorferi and Babesia microti.
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共感染伯氏疏螺旋体和田鼠巴贝斯虫的小鼠关节炎严重程度增加。
DOI：
10.1086/341452
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Persing,DavidH
中科院分区：
文献类型：
--
作者：
Moro,ManuelH;Zegarra-Moro,OfeliaL;Bjornsson,Johannes;Hofmeister,ErikK;Bruinsma,Elizabeth;Germer,JeffreyJ;Persing,DavidH
Increased severity of disease and persistence of symptoms have been recently reported in some patients with simultaneous infection ofBorrelia burgdorferiandBabesia microtiin the northeastern and northern midwest United States. This study used a murine model to examine whether defined disease conditions such as arthritis and carditis differed in severity in mice infected solely withB. burgdorferiand in mice coinfected withB. microtiandB. burgdorferi. C3H.HeJ and BALB/c mice cohorts were coinfected or singly infected and then monitored experimentally for 15 and 30 days after inoculation. Carditis and arthritis was determined by blinded histopathologic evaluation of myocardium and tibiotarsal joints. Cytokine measurements were made on lymph node and spleen supernatants for interferon-γ, interleukin (IL)–4, IL-10, and IL-13. No differences were observed for C3H.HeJ mice cohorts; however, coinfected BALB/c mice had a significant increase in arthritis severity at day 30. This clinical observation was correlated with a significant reduction in expression of the cytokines IL-10 and IL-13
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DOI：
10.1001/jama.1996.03530450047031
发表时间：
1996-06
期刊：
JAMA
影响因子：
--
作者：
P. Krause;S. Telford;A. Spielman;V. Sikand;R. Ryan;D. Christianson;G. Burke;P. Brassard;R. Pollack;J. Peck;D. Persing
通讯作者：
P. Krause;S. Telford;A. Spielman;V. Sikand;R. Ryan;D. Christianson;G. Burke;P. Brassard;R. Pollack;J. Peck;D. Persing
影响因子：
158.5
作者：
Krause, PJ;Spielman, A;Persing, DH
通讯作者：
Persing, DH
DOI：
--
发表时间：
1991-08
期刊：
The American journal of pathology
影响因子：
--
作者：
S. Barthold;D. Persing;Audrey L. Armstrong;Ruth A. Peeples
通讯作者：
S. Barthold;D. Persing;Audrey L. Armstrong;Ruth A. Peeples
影响因子：
11.8
作者：
Wang, TJ;Liang, MH;Shadick, NA
通讯作者：
Shadick, NA