Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia.
Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia.
复制标题
精神分裂症患者大脑皮层局部同步性的图谱改变。
DOI：
10.1192/j.eurpsy.2023.2463
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发表时间：
2023-10-18
影响因子：
7.8
通讯作者：
Blanco-Hinojo, Laura
中科院分区：
文献类型：
--
作者：
Pujol, Jesus;Pujol, Nuria;Mane, Anna;Martinez-Vilavella, Gerard;Deus, Joan;Perez-Sola, Victor;Blanco-Hinojo, Laura
Observations from different fields of research coincide in indicating that a defective gamma-aminobutyric acid (GABA) interneuron system may be among the primary factors accounting for the varied clinical expression of schizophrenia. GABA interneuron deficiency is locally expressed in the form of neural activity desynchronization. We mapped the functional anatomy of local synchrony in the cerebral cortex in schizophrenia using functional connectivity MRI. Data from 86 patients with schizophrenia and 137 control subjects were obtained from publicly available repositories. Resting-state functional connectivity maps based on Iso-Distant Average Correlation measures across three distances were estimated detailing the local functional structure of the cerebral cortex. Patients with schizophrenia showed weaker local functional connectivity (i.e., lower MRI signal synchrony) in (i) prefrontal lobe areas, (ii) somatosensory, auditory, visual, and motor cortices, (iii) paralimbic system at the anterior insula and anterior cingulate cortex, and (iv) hippocampus. The distribution of the defect in cortical area synchrony largely coincided with the synchronization effect of the GABA agonist alprazolam previously observed using identical functional connectivity measures. There was also a notable resemblance between the anatomy of our findings and cortical areas showing higher density of parvalbumin (prefrontal lobe and sensory cortices) and somatostatin (anterior insula and anterior cingulate cortex) GABA interneurons in humans. Our results thus provide detail of the functional anatomy of synchrony changes in the cerebral cortex in schizophrenia and suggest which elements of the interneuron system are affected. Such information could ultimately be relevant in the search for specific treatments.
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影响因子：
4.5
作者：
Heckers, Stephan;Konradi, Christine
通讯作者：
Konradi, Christine
影响因子：
5.7
作者：
Çetin MS;Christensen F;Abbott CC;Stephen JM;Mayer AR;Cañive JM;Bustillo JR;Pearlson GD;Calhoun VD
通讯作者：
Calhoun VD
影响因子：
2.5
作者：
Chen LM;Yang PF;Wang F;Mishra A;Shi Z;Wu R;Wu TL;Wilson GH 3rd;Ding Z;Gore JC
通讯作者：
Gore JC
影响因子：
3.4
作者：
Blanco-Hinojo, Laura;Pujol, Jesus;Deus, Joan
通讯作者：
Deus, Joan
影响因子：
64.8
作者：
Hawrylycz, Michael J.;Lein, Ed S.;Guillozet-Bongaarts, Angela L.;Shen, Elaine H.;Ng, Lydia;Miller, Jeremy A.;van de lagemaat, Louie N.;Smith, Kimberly A.;Ebbert, Amanda;Riley, Zackery L.;Abajian, Chris;Beckmann, Christian F.;Bernard, Amy;Bertagnolli, Darren;Boe, Andrew F.;Cartagena, Preston M.;Chakravarty, M. Mallar;Chapin, Mike;Chong, Jimmy;Dalley, Rachel A.;Daly, Barry David;Dang, Chinh;Datta, Suvro;Dee, Nick;Dolbeare, Tim A.;Faber, Vance;Feng, David;Fowler, David R.;Goldy, Jeff;Gregor, Benjamin W.;Haradon, Zeb;Haynor, David R.;Hohmann, John G.;Horvath, Steve;Howard, Robert E.;Jeromin, Andreas;Jochim, Jayson M.;Kinnunen, Marty;Lau, Christopher;Lazarz, Evan T.;Lee, Changkyu;Lemon, Tracy A.;Li, Ling;Li, Yang;Morris, John A.;Overly, Caroline C.;Parker, Patrick D.;Parry, Sheana E.;Reding, Melissa;Royall, Joshua J.;Schulkin, Jay;Sequeira, Pedro Adolfo;Slaughterbeck, Clifford R.;Smith, Simon C.;Sodt, Andy J.;Sunkin, Susan M.;Swanson, Beryl E.;Vawter, Marquis P.;Williams, Derric;Wohnoutka, Paul;Zielke, H. Ronald;Geschwind, Daniel H.;Hof, Patrick R.;Smith, Stephen M.;Koch, Christof;Grant, Seth G. N.;Jones, Allan R.
通讯作者：
Jones, Allan R.