Thalamus and posterior temporal lobe show greater inter-network connectivity at rest and across sensory paradigms in schizophrenia.
Thalamus and posterior temporal lobe show greater inter-network connectivity at rest and across sensory paradigms in schizophrenia.
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DOI：
10.1016/j.neuroimage.2014.04.009
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发表时间：
2014-08-15
期刊：
影响因子：
5.7
通讯作者：
Calhoun VD
中科院分区：
文献类型：
--
作者：
Çetin MS;Christensen F;Abbott CC;Stephen JM;Mayer AR;Cañive JM;Bustillo JR;Pearlson GD;Calhoun VD
虽然最近的一些研究考察了静止时的功能连接，但很少有人评估休息时和活动任务范例之间的连接之间的差异。因此，大脑皮层连接模式是保持稳定还是随着任务投入而变化的问题仍然没有得到解决。我们收集了健康对照组(N=53)和精神分裂症患者(N=42)在静息状态下的多扫描fMRI数据以及按感觉负荷分级排列的范式。我们测量了45个非人工的不同大脑网络之间的功能网络连接。然后，我们应用了一种新的分析来评估适用于健康对照组和精神分裂症患者的跨范式连接模式。为了检测这些模式，我们将GROUP BY TASK全因素方差模型与组平均功能网络连接值进行拟合。我们的方法确定了大脑连通性中的稳定(静态效应)和基于状态的差异(动态效应)，从而更好地理解了个体对简单感觉刺激的反应是如何受到呈现它们的环境的制约的。我们的发现表明，并不是所有在休息时观察到的群体差异在其他认知状态下都能被检测到。此外，在不同任务中，多个大脑区域与丘脑的连接性增强的稳定差异，突显了丘脑作为感觉输入的门户的重要性，并为精神分裂症提供了新的见解。
Although a number of recent studies have examined functional connectivity at rest, few have assessed differences between connectivity both during rest and across active task paradigms. Therefore, the question of whether cortical connectivity patterns remain stable or change with task engagement continues to be unaddressed. We collected multi-scan fMRI data on healthy controls (N = 53) and schizophrenia patients (N = 42) during rest and across paradigms arranged hierarchically by sensory load. We measured functional network connectivity among 45 non-artifactual distinct brain networks. Then, we applied a novel analysis to assess cross paradigm connectivity patterns applied to healthy controls and patients with schizophrenia. To detect these patterns, we fit a group by task full factorial ANOVA model to the group average functional network connectivity values. Our approach identified both stable (static effects) and state-based differences (dynamic effects) in brain connectivity providing a better understanding of how individuals’ reactions to simple sensory stimuli are conditioned by the context within which they are presented. Our findings suggest that not all group differences observed during rest are detectable in other cognitive states. In addition, the stable differences of heightened connectivity between multiple brain areas with thalamus across tasks underscore the importance of the thalamus as a gateway to sensory input and provide new insight into schizophrenia.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
在认知控制性能过程中，第一期精神分裂症中的一般和特定的功能连通性干扰。
影响因子：
10.6
作者：
Fornito, Alex;Yoon, Jong;Zalesky, Andrew;Bullmore, Edward T.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
5.7
作者：
Bassett, Danielle S.;Nelson, Brent G.;Mueller, Bryon A.;Camchong, Jazmin;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.
DOI：
10.1109/titb.2008.923773
发表时间：
2009-09-01
影响因子：
--
作者：
Calhoun, Vince D.;Adali, Tuelay
通讯作者：
Adali, Tuelay
影响因子：
3.7
作者：
Allen, Elena A.;Damaraju, Eswar;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.