Effects of n-butanol and water fractions from Pedicularis decora Franch on oxidative stress in mice induced by a single bout of swimming exercise

Effects of n-butanol and water fractions from Pedicularis decora Franch on oxidative stress in mice induced by a single bout of swimming exercise
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马先蒿正丁醇和水部分对单次游泳运动诱发的小鼠氧化应激的影响

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2011
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本研究探讨了美丽马先蒿根的水和正丁醇部位对游泳运动诱导的氧化应激的影响。ICR小鼠口服水和正丁醇组分三周。久坐小鼠脂质过氧化(LPO)水平、转氨酶活性显著降低,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)活性、血红蛋白(Hb)和糖原浓度显著升高。结果还表明,水提物和正丁醇提取物通过降低小鼠体内LPO水平、SOD、GPx、LDH、转氨酶活性和升高血红蛋白、糖原和葡萄糖浓度,保护小鼠免受一次游泳运动引起的氧化应激。综上所述,来自美丽海葵的两个级分改善了由单次游泳引起的氧化应激。正丁醇级分比水级分更有效。
This study investigated the effect of water and n-butanol fractions from Pedicularis decora Franch roots on oxidative stress induced by a single bout of swimming exercise. ICR mice were treated orally with water and n-butanol fractions for three weeks. Lipid peroxidation (LPO) levels, transaminases activities significantly decreased and superoxide dismutases (SOD), glutathione peroxidase (GPx) activities, haemoglobin (Hb) and glycogen concentrations significantly increased in sedentary mice. The results also showed that the water and n-butanol fractions protected mice from a single bout swimming exercise induced oxidative stress through a decrease in LPO levels, SOD, GPx, LDH, transaminases activities and an increase in Hb, glycogen and glucose concentrations. Taken together, the two fractions from P. decora ameliorated the oxidative stress induced by a single bout of swimming. The nbutanol fraction is more effective than the water fraction.
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