Understanding the mechanisms of viral induced asthma: new therapeutic directions.
Understanding the mechanisms of viral induced asthma: new therapeutic directions.
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DOI：
10.1016/j.pharmthera.2007.11.002
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发表时间：
2008-03
影响因子：
13.5
通讯作者：
Hansbro PM
中科院分区：
文献类型：
--
作者：
Hansbro NG;Horvat JC;Wark PA;Hansbro PM
哮喘是一种常见的、令人衰弱的疾病，在过去20年里，这种疾病在西方社会的患病率大幅上升。呼吸道合胞病毒(RSV)和鼻病毒(RV)的呼吸道感染被广泛认为是哮喘诱发和加重的常见原因。这些早期生命中的感染与可能发展为哮喘的喘息的诱导有关。感染还可能促进呼吸道炎症和增强T辅助2型淋巴细胞(Th2细胞)的反应，从而导致既往哮喘的恶化。RSV和RV如何诱发和加重哮喘的机制目前正在通过临床研究、体外与人类细胞和动物疾病模型的研究来阐明。这项研究已经产生了许多潜在的治疗策略，虽然还没有进入临床实践，但它们在预防和治疗病毒性疾病和随后的哮喘方面显示出很大的希望。
Asthma is a common and debilitating disease that has substantially increased in prevalence in Western Societies in the last 2 decades. Respiratory tract infections by respiratory syncytial virus (RSV) and rhinovirus (RV) are widely implicated as common causes of the induction and exacerbation of asthma. These infections in early life are associated with the induction of wheeze that may progress to the development of asthma. Infections may also promote airway inflammation and enhance T helper type 2 lymphocyte (Th2 cell) responses that result in exacerbations of established asthma. The mechanisms of how RSV and RV induce and exacerbate asthma are currently being elucidated by clinical studies, in vitro work with human cells and animal models of disease. This research has led to many potential therapeutic strategies and, although none are yet part of clinical practise, they show much promise for the prevention and treatment of viral disease and subsequent asthma.
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