Functional aspects of primary cilium in signaling, assembly and microenvironment in cancer.
Functional aspects of primary cilium in signaling, assembly and microenvironment in cancer.
复制标题
初级纤毛在癌症信号传导、组装和微环境中的功能。
DOI：
10.1002/jcp.30117
复制
发表时间：
2021-05
影响因子：
5.6
通讯作者：
Liu P
中科院分区：
文献类型：
--
作者：
Wang B;Liang Z;Liu P
The primary cilium is an antennae‐like structure extent outside the cell surface. It has an important role in regulating cell‐signaling transduction to affect proliferation, differentiation and migration. Evidence is accumulating that ciliary defects lead to ciliopathies and ciliary deregulation also play crucial roles in cancer formation and progression. Interestingly, restoring the cilia can suppress proliferation in some cancer cell. However, t he role of primary cilia in cancer still be debated. In this article, we review the role of the primary cilium in cancer through architecture, signaling pathways, cilia assembly and disassembly regulators, and summarized the new findings of the primary cilium in tumor microenvironments and different cancers, highlighting novel possibilities for therapeutic target in cancer. The role of the primary cilium in cancer.
登录
查看更多内容
影响因子：
7.3
作者：
Guinot, Anna;Lehmann, Holger;Frew, Ian J.
通讯作者：
Frew, Ian J.
影响因子：
30.8
作者：
Gerdes, Jantje M.;Liu, Yangfan;Katsanis, Nicholas
通讯作者：
Katsanis, Nicholas
影响因子：
5.3
作者：
Castiella T;Muñoz G;Luesma MJ;Santander S;Soriano M;Junquera C
通讯作者：
Junquera C
初级纤毛通过 Lkb1 调节 mTORC1 活性和细胞大小。
影响因子：
21.3
作者：
Boehlke, Christopher;Kotsis, Fruzsina;Patel, Vishal;Braeg, Simone;Voelker, Henriette;Bredt, Saskia;Beyer, Theresa;Janusch, Heike;Hamann, Christoph;Goedel, Markus;Mueller, Klaus;Herbst, Martin;Hornung, Miriam;Doerken, Mara;Koettgen, Michael;Nitschke, Roland;Igarashi, Peter;Walz, Gerd;Kuehn, E. Wolfgang
通讯作者：
Kuehn, E. Wolfgang
DOI：
10.1016/j.cub.2009.07.034
发表时间：
2009-09-15
期刊：
Current biology : CB
影响因子：
--
作者：
Anderson CT;Stearns T
通讯作者：
Stearns T