Will we ever use stem cells for the treatment of SUI? ICI-RS 2011.
Will we ever use stem cells for the treatment of SUI? ICI-RS 2011.
复制标题
DOI：
10.1002/nau.22217
复制
发表时间：
2012-03
影响因子：
2
通讯作者：
Damaser, Margot S.
中科院分区：
文献类型：
--
作者：
Goldman, Howard B.;Sievert, Karl-Dietrich;Damaser, Margot S.
回顾干细胞治疗压力性尿失禁(SUI)的研究现状，并评估其成为相关治疗选择的可能性。对有关SUI的相关临床和动物研究的同行评议文献进行了调查和综述。动物研究已经证明了干细胞在促进模拟分娩损伤后的尿路功能恢复方面的潜在效用。在动物身上的研究表明，注射骨髓间充质干细胞分泌物后的尿路恢复与注射干细胞后相似。因此，目前尚不清楚这种改善是来自干细胞本身的注射，还是来自它们分泌的特定蛋白质。早期的临床试验已经证明了将肌源性干细胞注射到尿路治疗SUI的可行性和短期安全性。需要进行更大规模和更长期的临床试验。尽管如此，基于干细胞的治疗SUI的有效方法是实用的、可实现的，并且应该在不久的将来成为一种治疗方式。
To review the current state of research in the use of stem cells for stress urinary incontinence (SUI) and assess the likelihood of this becoming a relevant treatment option. The peer-reviewed literature consisting of relevant clinical and animal studies on the topic of SUI was surveyed and reviewed. Animal studies have demonstrated the potential utility of stem cells in promoting functional recovery of the urethra after simulated childbirth injury. Research in animals suggests similar urethral recovery after injection of bone-marrow derived mesenchymal stem cell secretions as after injection of the stem cells themselves. Therefore, whether the improvements result from the injection of the stem cells themselves or from their secretion of specific proteins is unclear. Early clinical trials have demonstrated the feasibility and short-term safety of injecting muscle-derived stem cells into the urethra to treat SUI. Larger and longer term clinical trials are needed. Nonetheless, efficacious stem cell based therapy for the treatment of SUI is practical, achievable and should be available as a treatment modality in the near future.
登录
查看更多内容
影响因子：
23.4
作者：
Zhao, Weiming;Zhang, Cheng;Xiu, Youcheng
通讯作者：
Xiu, Youcheng
影响因子：
1.6
作者：
Kim, Sun-Ouck;Na, Hee Sam;Ahn, Youngkeun
通讯作者：
Ahn, Youngkeun
影响因子：
2.1
作者：
Chermansky, CJ;Tarin, T;Chancellor, MB
通讯作者：
Chancellor, MB
DOI：
10.1111/j.1749-6632.2009.04610.x
发表时间：
2009-01-01
期刊：
HEMATOPOIETIC STEM CELLS VII
影响因子：
--
作者：
Drost, Adriana C.;Weng, Sibylle;Moehle, Robert
通讯作者：
Moehle, Robert
影响因子：
168.9
作者：
Strasser, Hannes;Marksteiner, Rainer;Bartsch, Georg
通讯作者：
Bartsch, Georg