Vertebrobasilar Flow Evaluation and Risk of Transient Ischaemic Attack and Stroke study (VERiTAS): rationale and design.
Vertebrobasilar Flow Evaluation and Risk of Transient Ischaemic Attack and Stroke study (VERiTAS): rationale and design.
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DOI：
10.1111/j.1747-4949.2010.00528.x
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
VERiTAS Study Group
中科院分区：
文献类型：
--
作者：
Amin-Hanjani S;Rose-Finnell L;Richardson D;Ruland S;Pandey D;Thulborn KR;Liebeskind DS;Zipfel GJ;Elkind MS;Kramer J;Silver FL;Kasner SE;Caplan LR;Derdeyn CP;Gorelick PB;Charbel FT;VERiTAS Study Group
Over one third of ischemic strokes occur in the posterior circulation, a leading cause of which is atherosclerotic vertebrobasilar disease (VBD). Symptomatic VBD carries a high annual recurrent stroke risk, averaging 10–15% per year. Endovascular angioplasty and stenting are increasingly employed, but carry risks, and the benefit remains unproven. Determining stroke predictors in this population is critical to identifying high risk patients for future trials of intervention. Preliminary studies indicate that stroke risk in VBD is strongly related to hemodynamic compromise, which can be measured noninvasively using quantitative magnetic resonance angiography (QMRA). The VERiTAS Study, a prospective multi-center NIH funded observational study of symptomatic vertebrobasilar stenosis (≥ 50%) or occlusion, is designed to test the hypothesis that patients demonstrating compromised blood flow as assessed by QMRA are at higher stroke risk. The study will recruit 80 patients at 6 sites in North America over four years. Upon enrollment, subjects will undergo hemodynamic assessment with blinded QMRA to assess large vessel flow in the vertebrobasilar territory, and be prospectively designated as compromised or normal flow. Patients will be reimaged with QMRA at 6, 12 and 24 months, and followed for 12 to 24 months for the primary endpoint of stroke in the vertebrobasilar territory. VERiTAS is the first prospective study of hemodynamics and stroke risk in the posterior circulation. The results may impact the selection criteria for interventional candidates and also define a low risk population in whom the risks of invasive interventions would be unnecessary.
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影响因子：
3.5
作者：
Zhao, M.;Amin-Hanjani, S.;Charbel, F. T.
通讯作者：
Charbel, F. T.
影响因子：
2.5
作者：
Zhao, M;Charbel, FT;Clark, ME
通讯作者：
Clark, ME
影响因子：
3.3
作者：
HOFMAN, MBM;VISSER, FC;WESTERHOF, N
通讯作者：
WESTERHOF, N
影响因子：
8.3
作者：
Ogasawara, K;Ogawa, A;Yoshimoto, T
通讯作者：
Yoshimoto, T
影响因子：
3.3
作者：
MEIER, D;MAIER, S;BOSIGER, P
通讯作者：
BOSIGER, P