Estimation of delivered dose in radiotherapy: the influence of registration uncertainty.
Estimation of delivered dose in radiotherapy: the influence of registration uncertainty.
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DOI：
10.1007/978-3-642-23623-5_69
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Wells, William M.
中科院分区：
文献类型：
--
作者：
Risholm, Petter;Balter, James;Wells, William M.
我们提出了一个概率框架来估计累积的辐射剂量和相应的剂量不确定性，被传递到重要的解剖结构，如原发性肿瘤和健康的周围器官，在放疗过程中。我们报告的剂量不确定性是变形估计的不确定性的直接结果，该变形将日常锥束CT图像与计划CT对齐。累积辐射剂量是在治疗期间监测的重要措施，特别是查看其是否显著偏离计划剂量，这可能表明患者在治疗前未正确定位或解剖结构由于治疗而发生变化。在后者的情况下，治疗计划应自适应地改变，以与当前患者解剖结构对齐。我们估计的累积剂量分布，其不确定性，回顾性地在颈部癌症治疗过程中获得的数据集，并显示剂量体积直方图的形式的剂量分布。
We present a probabilistic framework to estimate the accumulated radiation dose and the corresponding dose uncertainty that is delivered to important anatomical structures, e.g. the primary tumor and healthy surrounding organs, during radiotherapy. The dose uncertainty we report is a direct result of uncertainties in the estimates of the deformation which aligns the daily cone-beam CT images with the planning CT. The accumulated radiation dose is an important measure to monitor during treatment, in particular to see if it significantly deviates from the planned dose which might indicate that either the patient was not properly positioned before treatment or that the anatomy has changed due to the treatment. In the case of the latter, the treatment plan should be adaptively changed to align with the current patient anatomy. We estimate the accumulated dose distribution, and its uncertainty, retrospectively on a dataset acquired during treatment of cancer in the neck and show the dose distributions in the form of dose volume histograms.
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影响因子：
3.5
作者：
Sykes, J. R.;Brettle, D. S.;Thwaites, D. I.
通讯作者：
Thwaites, D. I.
DOI：
10.1016/0360-3016(91)90168-4
发表时间：
1991-05-15
影响因子：
7
作者：
DRZYMALA, RE;MOHAN, R;URIE, M
通讯作者：
URIE, M
影响因子：
3.5
作者：
Lu, Weiguo;Olivera, Gustavo H.;Kupelian, Patrick A.
通讯作者：
Kupelian, Patrick A.
DOI：
10.1016/j.ijrobp.2004.07.696
发表时间：
2005-03-01
影响因子：
7
作者：
Hong, TS;Tomé, WA;Harari, PM
通讯作者：
Harari, PM