The area postrema (AP) and the parabrachial nucleus (PBN) are important sites for salmon calcitonin (sCT) to decrease evoked phasic dopamine release in the nucleus accumbens (NAc).
The area postrema (AP) and the parabrachial nucleus (PBN) are important sites for salmon calcitonin (sCT) to decrease evoked phasic dopamine release in the nucleus accumbens (NAc).
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面积Postrema（AP）和副核核（PBN）是鲑鱼降钙素（SCT）的重要部位，可降低伏隔核（NAC）中诱发的质量多巴胺释放。
DOI：
10.1016/j.physbeh.2017.03.023
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发表时间：
2017-07-01
影响因子：
2.9
通讯作者：
Lutz TA
中科院分区：
文献类型：
--
作者：
Whiting L;McCutcheon JE;Boyle CN;Roitman MF;Lutz TA
胰腺激素胰胰素及其激动剂鲑鱼降钙素（sCT）通过后脑区（AP）和外侧臂旁核（PBN）起作用，以减少食物摄入。对腹侧被盖区（VTA）和伏隔核（NAc）的胰淀素和sCT信号的研究表明，胰淀素的进食抑制作用部分是通过中脑边缘“奖励”途径介导的。事实上，直接给药于VTA减少了NAc的阶段性多巴胺释放（DA）。然而，尚不清楚外周胰淀素是否直接调节中边缘系统，还是通过AP和PBN发生。为了确定外周胰淀素或sCT是否以及如何影响中脑边缘奖励回路，我们在麻醉下使用快速扫描循环伏安法测量电刺激完整大鼠、AP损伤大鼠和双侧PBN损伤大鼠的VTA引起的NAc的相性DA释放。与生理盐水对照大鼠相比，胰淀素（50 μg/kg i.p）未改变相性DA反应。然而，与生理盐水处理的对照大鼠相比，sCT （50 μg/kg i.p）在1小时内减少了vta刺激引起的DA释放。进一步的研究表明，AP和双侧PBN病变消除了sCT抑制vta刺激引起的相性DA反应的能力。这些发现暗示AP和PBN是外周sCT减少NAc中诱发的DA释放的重要位点，并表明这些核可能影响享乐和动机过程来调节食物摄入。
The pancreatic hormone amylin and its agonist salmon calcitonin (sCT) act via the area postrema (AP) and the lateral parabrachial nucleus (PBN) to reduce food intake. Investigations of amylin and sCT signaling in the ventral tegmental area (VTA) and nucleus accumbens (NAc) suggest that the eating inhibitory effect of amylin is, in part, mediated through the mesolimbic ‘reward’ pathway. Indeed, administration of the sCT directly to the VTA decreased phasic dopamine release (DA) in the NAc. However, it is not known if peripheral amylin modulates the mesolimbic system directly or whether this occurs via the AP and PBN. To determine whether and how peripheral amylin or sCT affect mesolimbic reward circuitry we utilized fast scan cyclic voltammetry under anesthesia to measure phasic DA release in the NAc evoked by electrical stimulation of the VTA in intact, AP lesioned and bilaterally PBN lesioned rats. Amylin (50 μg/kg i.p.) did not change phasic DA responses compared to saline control rats. However, sCT (50 μg/kg i.p.) decreased evoked DA release to VTA-stimulation over 1 h compared to saline treated control rats. Further investigations determined that AP and bilateral PBN lesions abolished the ability of sCT to suppress evoked phasic DA responses to VTA-stimulation. These findings implicate the AP and the PBN as important sites for peripheral sCT to decrease evoked DA release in the NAc and suggest that these nuclei may influence hedonic and motivational processes to modulate food intake.
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影响因子：
5.5
作者：
Jordi, Josua;Herzog, Brigitte;Verrey, Francois
通讯作者：
Verrey, Francois
影响因子：
7.3
作者：
Bailey, R. J.;Walker, C. S.;Hay, D. L.
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影响因子：
4.9
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
29
作者：
Campos CA;Bowen AJ;Schwartz MW;Palmiter RD
通讯作者：
Palmiter RD