The Balance between the Left and Right Ventricular Deformation Evaluated by Speckle Tracking Echocardiography Is a Great Predictor of the Major Adverse Cardiac Event in Patients with Pulmonary Hypertension.
The Balance between the Left and Right Ventricular Deformation Evaluated by Speckle Tracking Echocardiography Is a Great Predictor of the Major Adverse Cardiac Event in Patients with Pulmonary Hypertension.
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DOI：
10.3390/diagnostics12092266
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发表时间：
2022-09-19
期刊：
影响因子：
3.6
通讯作者：
Shen, Jieyan
中科院分区：
文献类型：
--
作者：
Zhang, Xueming;Ruan, Binqian;Qiao, Zhiqing;Yang, Menghui;Zhuang, Qi;Wang, Jian;Wang, Wei;Zheng, Ying;Zhao, Hang;Shen, Xuedong;Shen, Jieyan
心血管衰竭是肺动脉高压（PH）死亡的最相关原因之一。随着 PH 患者右心室 (RV) 后负荷逐渐增加，右心室 (RV) 和左心室 (LV) 功能均受损，并且 RV-LV 不同步同时发生。我们的目的是通过斑点追踪超声心动图分析左心室和右心室变形之间的平衡来评估肺动脉高压患者的预后。在这项前瞻性研究中，纳入了 54 名经侵入性诊断的肺动脉高压患者和 26 名健康志愿者，并接受了广泛的无创评估，包括 2D 超声心动图、2D 斑点追踪、6 分钟步行测试和 BNP。对患者进行了 338.7 ± 131.1（范围 60 至 572）天的随访。 |LVGLS/RVFLS-1| 存在显着差异和 |LASc/RASc-1| PH 患者与对照组之间的差异。随访期间，13例患者出现MACE，其中7例心源性死亡，6例因右心功能不全再次入院。在多元Cox模型分析中，|LVGLS/RVFLS-1|仍然是独立的预后标志物（HR = 4.03）。我们的研究结果表明 |LVGLS/RVFLS-1|对肺动脉高压患者具有高度的临床和预后相关性，并揭示了左心室和右心室变形之间平衡的重要性。
Cardiovascular failure is one of the most relevant causes of death in pulmonary hypertension (PH). With progressive increases of right ventricular (RV) afterload in PH patients, both RV and left ventricular (LV) function impair and RV–LV dyssynchrony develop in parallel. We aimed to analyze the balance between the left and right ventricular deformation to assess the outcome of patients with pulmonary hypertension by means of speckle tracking echocardiography. In this prospective study, 54 patients with invasively diagnosed pulmonary hypertension, and 26 healthy volunteers were included and underwent a broad panel of noninvasive assessment including 2D-echocardiography, 2D speckle tracking, 6-minute walking test and BNP. Patients were followed up for 338.7 ± 131.1 (range 60 to 572) days. There were significant differences in |LVGLS/RVFLS-1| and |LASc/RASc-1| between PH patients and the control group. During the follow up, 13 patients experienced MACEs, which included 7 patients with cardiac death and 6 patients with re-admitted hospital due to right ventricular dysfunction. In the multivariate Cox model analysis, |LVGLS/RVFLS-1| remained independent prognosis of markers (HR = 4.03). Our study findings show that |LVGLS/RVFLS-1| is of high clinical and prognostic relevance in pulmonary hypertension patients and reveal the importance of the balance between the left and right ventricular deformation.
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影响因子：
18.2
作者：
Bosch, Lena;Lam, Carolyn S. P.;Ling, Lieng H.
通讯作者：
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