Shared space, separate processes: Neural activation patterns for auditory description and visual object naming in healthy adults.
Shared space, separate processes: Neural activation patterns for auditory description and visual object naming in healthy adults.
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DOI：
10.1002/hbm.22345
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发表时间：
2014-06
影响因子：
4.8
通讯作者：
Hirsch, Joy
中科院分区：
文献类型：
--
作者：
Hamberger, Marla J.;Habeck, Christian G.;Pantazatos, Spiro P.;Williams, Alicia C.;Hirsch, Joy
从历史上看，临床医生和认知科学家都使用视觉对象命名措施来研究命名，病变类型研究表明左后颞顶叶区域是命名回路的关键组成部分。然而，最近的结果，从行为和皮质刺激研究，使用听觉描述命名以及视觉对象命名在左颞叶癫痫患者表明，离散的网站在前颞叶皮层的描述命名是至关重要的，而后颞区调解视觉对象命名和描述命名。为了确定这种任务特异性是否反映了正常的大脑组织和处理，13名健康成年人在功能性神经成像过程中进行了描述命名和视觉命名。除了标准的单变量分析，多变量，有序趋势分析研究了网络字符的区域参与特定任务的命名。单变量分析表明后颞激活视觉命名和描述命名，而多变量分析揭示了更广泛的网络，这两个任务，重叠和任务特定的区域，以及任务相关的差异，任务利用共同的区域。此外，多变量分析揭示了独特的、任务特定的、区域共变的激活模式，所有13名视觉命名受试者和12/13名描述命名受试者的激活模式惊人地一致。结果表明，一个共同的神经基板，但可区分的神经过程的视觉命名和描述命名在神经系统完整的个人。这些研究结果支持使用这两种类型的任务进行临床评估，并可能在治疗神经命名缺陷的应用。
Historically, both clinicians and cognitive scientists have used visual object naming measures to study naming, and lesion-type studies have implicated the left posterior, temporo-parietal region as a critical component of naming circuitry. However, recent results from behavioral and cortical stimulation studies using auditory description naming as well as visual object naming in left temporal lobe epilepsy patients suggest that discrete sites in anterior temporal cortex are critical for description naming, whereas posterior temporal regions mediate both visual object naming and description naming. To determine whether this task specificity reflects normal cerebral organization and processing, 13 healthy adults performed description naming and visual naming during functional neuroimaging. In addition to standard univariate analysis, multivariate, Ordinal Trend Analysis examined the network character of the regions involved in task-specific naming. Univariate analysis indicated posterior temporal activation for both visual naming and description naming, whereas multivariate analysis revealed broader networks for both tasks, with both overlapping and task-specific regions, as well as task related differences in the way the tasks utilized common regions. Additionally, multivariate analysis revealed unique, task-specific, regionally covarying activation patterns that were strikingly consistent in all 13 subjects for visual naming and 12/13 subjects for description naming. Results suggest a common neural substrate, yet differentiable neural processes underlying visual naming and description naming in neurologically intact individuals. These findings support the use of both types of tasks for clinical assessment, and may have application in the treatment of neurologically based naming deficits.
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