AMPK at the crossroads of circadian clocks and metabolism.
AMPK at the crossroads of circadian clocks and metabolism.
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DOI：
10.1016/j.mce.2012.06.017
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发表时间：
2013-02-25
影响因子：
4.1
通讯作者：
Lamia, Katja A.
中科院分区：
文献类型：
--
作者：
Jordan, Sabine D.;Lamia, Katja A.
生物钟协调行为和生理与日常环境周期，从而优化代谢过程的时间，如葡萄糖生产和胰岛素分泌。这种代谢的昼夜节律在不同的生物体中提供了一种适应性优势。哺乳动物的时钟主要基于转录和翻译反馈环，在该环中，转录因子CLOCK(昼夜运动输出周期kaput)和BMAL1(脑和肌肉Arnt样蛋白1)的异二聚体复合体激活其自身的阻遏蛋白PER1-3和隐色素(CRY1，2)的表达。这些核心时钟组件的翻译后修改对于设置时钟时间或调整时钟速度至关重要。AMP激活的蛋白激酶(AMPK)是几种代谢传感器之一，已被报道将能量依赖的信号传递给哺乳动物的时钟。AMPK通过驱动CRY和PER蛋白的磷酸化和失稳来实现这一点。此外，AMPK亚基组成、亚细胞定位和底物磷酸化都依赖于时钟时间。鉴于AMPK在代谢生理的各个方面的广泛作用，AMPK和生物钟的相互调节可能在昼夜代谢调节中发挥重要作用。
Circadian clocks coordinate behavior and physiology with daily environmental cycles and thereby optimize the timing of metabolic processes such as glucose production and insulin secretion. Such circadian regulation of metabolism provides an adaptive advantage in diverse organisms. Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex of the transcription factors CLOCK (circadian locomotor output cycles kaput) and BMAL1 (brain and muscle Arnt-like protein 1) activates the expression of its own repressors, the period (PER1-3) and cryptochrome (CRY1,2) proteins. Posttranslational modification of these core clock components is critical for setting clock time or adjusting the speed of the clock. AMP-activated protein kinase (AMPK) is one of several metabolic sensors that have been reported to transmit energy-dependent signals to the mammalian clock. AMPK does so by driving the phosphorylation and destabilization of CRY and PER proteins. In addition, AMPK subunit composition, sub-cellular localization, and substrate phosphorylation are dependent on clock time. Given the well-established role of AMPK in diverse aspects of metabolic physiology, the reciprocal regulation of AMPK and circadian clocks likely plays an important role in circadian metabolic regulation.
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影响因子：
29
作者：
Bai P;Canto C;Brunyánszki A;Huber A;Szántó M;Cen Y;Yamamoto H;Houten SM;Kiss B;Oudart H;Gergely P;Menissier-de Murcia J;Schreiber V;Sauve AA;Auwerx J
通讯作者：
Auwerx J
影响因子：
3.5
作者：
Davies, SP;Helps, NR;Hardie, DG
通讯作者：
Hardie, DG
影响因子：
3.5
作者：
Hall, AC;Hoffmaster, RM;Bickar, D
通讯作者：
Bickar, D
影响因子：
11.8
作者：
Fulco, Marcella;Cen, Yana;Sartorelli, Vittorio
通讯作者：
Sartorelli, Vittorio
影响因子：
56.9
作者：
Balsalobre, A;Brown, SA;Schibler, U
通讯作者：
Schibler, U