The impact of clinical and demographic variables on cognitive performance in methamphetamine-dependent individuals in rural South Carolina.
The impact of clinical and demographic variables on cognitive performance in methamphetamine-dependent individuals in rural South Carolina.
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DOI：
10.1111/j.1521-0391.2011.00164.x
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Brady KT
中科院分区：
文献类型：
--
作者：
Price KL;DeSantis SM;Simpson AN;Tolliver BK;McRae-Clark AL;Saladin ME;Baker NL;Wagner MT;Brady KT
甲基苯丙胺（METH）相关认知功能障碍报告的增加可能至少部分归因于研究样本特征（卵、临床和人口统计学特征）的多样性。本研究评估了来自南卡罗来纳州农村的METH依赖人群的认知功能，以及人口统计学和临床特征对表现的影响。对71名男性（28.2%）和女性（71.8%）METH依赖者进行了一系列神经认知测试，包括记忆伪装测试（TOMM）、Shipley生活量表研究所、起搏听觉序列添加测试（PASAT）、符号数字模态测试（SDMT）、槽钉板测试、加州言语学习测试（CVLT）和威斯康星州卡片分类测试（WCST）。人口统计学和临床特征（鸡蛋，性别，使用METH的频率）作为性能的预测因素进行了检查。受试者在一项注意力测试和一项精细运动功能测试中的得分显着低于预期，但在所有其他测试中表现良好。有没有预测性能的注意力，但是，更频繁地使用METH与更好的性能男性和女性的精细运动技能差。该人群中的METH依赖个体表现出非常有限的认知障碍。与已发表的文献相比，我们样本中的教育、智商（IQ）和性别的显著差异可能有助于这些发现。临床和/或人口统计学特征对认知缺陷的影响的表征在指导治疗干预措施的制定方面可能很重要。
Inconsistencies in reports on methamphetamine (METH) associated cognitive dysfunction may be attributed, at least in part, to the diversity of study sample features (egg, clinical and demographic characteristics). The current study assessed cognitive function in a METH-dependent population from rural South Carolina, and the impact of demographic and clinical characteristics on performance. Seventy-one male (28.2%) and female (71.8%) METH-dependent subjects were administered a battery of neurocognitive tests including the Test of Memory Malingering (TOMM), Shipley Institute of Living Scale, Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), Grooved Pegboard Test, California Verbal Learning Test (CVLT), and Wisconsin Card Sorting Test (WCST). Demographic and clinical characteristics (egg, gender, frequency of METH use) were examined as predictors of performance. Subjects scored significantly lower than expected on one test of attention and one of fine motor function, but performed adequately on all other tests. There were no predictors of performance on attention; however, more frequent METH use was associated with better performance for males and worse for females on fine motor skills. The METH-dependent individuals in this population exhibit very limited cognitive impairment. The marked differences in education, Intellectual Quotient (IQ), and gender in our sample when compared to the published literature may contribute to these findings. Characterization of the impact of clinical and/or demographic features on cognitive deficits could be important in guiding the development of treatment interventions.
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影响因子：
6
作者：
Chang, Linda;Alicata, Daniel;Volkow, Nora
通讯作者：
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DOI：
10.1176/appi.neuropsych.12.4.480
发表时间：
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