Multiplexing stimulus information through rate and temporal codes in primate somatosensory cortex.
Multiplexing stimulus information through rate and temporal codes in primate somatosensory cortex.
复制标题
DOI：
10.1371/journal.pbio.1001558
复制
发表时间：
2013
期刊：
影响因子：
9.8
通讯作者：
Bensmaia SJ
中科院分区：
文献类型：
--
作者：
Harvey MA;Saal HP;Dammann JF 3rd;Bensmaia SJ
在躯体感觉皮层中，刺激幅度以相对粗糙的时间分辨率表示，而刺激频率由精确计时的动作电位表示。我们感知和辨别纹理的能力依赖于指尖扫描表面时引起的复杂高频振动的转换和处理。自然主义的振动，以及延伸的纹理，是如何在初级躯体感觉皮层（S1）的神经元反应中编码的，这是未知的。结合清醒猕猴的单单位记录和从人类受试者获得的感知判断，我们发现，振动幅度编码在S1神经元中诱发的反应强度。相比之下，振动的频率组成，高达800 Hz，不是在神经元放电率中编码的，而是在神经元亚群的锁相响应中编码的。此外，知觉判断的分析表明，尖峰时间不仅传达刺激信息，但形状的触觉知觉。我们的结论是，有关的振幅和频率的自然振动的信息是多路复用在不同的时间尺度在S1，并编码在响应的速率和时间模式，分别。当我们的指尖滑过纹理表面时，皮肤会产生微小、复杂和高频的振动，我们的神经系统会从这些振动中提取有关纹理的信息。在这项研究中，我们调查如何纹理样的振动处理的初级体感皮层（S1）。首先，我们表明，随时间变化的皮肤振动的振幅编码在S1神经元的一个亚群的随时间变化的响应率。第二，我们表明，S1神经元的这个相同的亚群产生的反应，其时间密切匹配的振动：尖峰模式的频率组成匹配的刺激，即使是复杂的振动。我们表明，这种时间精度是行为相关的振动的触觉感知更好地预测神经元反应时，尖峰定时考虑比当它不是。因此，S1神经元的活动在不同的时间尺度上是多路复用的：变化相对缓慢的刺激幅度以相对粗糙的时间分辨率表示，而刺激频率则由精确计时的动作电位表示。
In somatosensory cortex, stimulus amplitude is represented at a relatively coarse temporal resolution, while stimulus frequency is represented by precisely timed action potentials. Our ability to perceive and discriminate textures relies on the transduction and processing of complex, high-frequency vibrations elicited in the fingertip as it is scanned across a surface. How naturalistic vibrations, and by extension texture, are encoded in the responses of neurons in primary somatosensory cortex (S1) is unknown. Combining single unit recordings in awake macaques and perceptual judgments obtained from human subjects, we show that vibratory amplitude is encoded in the strength of the response evoked in S1 neurons. In contrast, the frequency composition of the vibrations, up to 800 Hz, is not encoded in neuronal firing rates, but rather in the phase-locked responses of a subpopulation of neurons. Moreover, analysis of perceptual judgments suggests that spike timing not only conveys stimulus information but also shapes tactile perception. We conclude that information about the amplitude and frequency of natural vibrations is multiplexed at different time scales in S1, and encoded in the rate and temporal patterning of the response, respectively. When we slide our fingertip across a textured surface, small, complex, and high-frequency vibrations are elicited in the skin and our nervous system extracts information about texture from these vibrations. In this study, we investigate how texture-like vibrations are processed in primary somatosensory cortex (S1). First, we show that the time-varying amplitude of skin vibrations is encoded in the time-varying response rates of a subpopulation of S1 neurons. Second, we show that this same subpopulation of S1 neurons produces responses whose timing closely matches that of the vibrations: The frequency composition of the spiking patterns matches that of the stimulus, even for complex vibrations. We demonstrate that this temporal precision is behaviorally relevant by showing that the tactile perception of vibration is better predicted from neuronal responses when spike timing is taken into consideration than when it is not. The activity of S1 neurons is thus multiplexed at different time scales: Stimulus amplitude, which changes relatively slowly, is represented at a relatively coarse temporal resolution, while stimulus frequency is represented by precisely timed action potentials.
登录
查看更多内容
影响因子：
2.5
作者：
Bensmaïa, SJ;Leung, YY;Johnson, KO
通讯作者：
Johnson, KO
DOI：
10.3758/bf03193537
发表时间：
2005-07-01
期刊：
PERCEPTION & PSYCHOPHYSICS
影响因子：
--
作者：
Bensmaïa, S;Hollins, M
通讯作者：
Hollins, M
影响因子：
2.5
作者：
MOUNTCASTLE, VB;TALBOT, WH;HYVARINEN, J
通讯作者：
HYVARINEN, J
影响因子：
0.9
作者：
Bensmaïa, SJ;Hollins, M
通讯作者：
Hollins, M
影响因子：
25
作者：
Friedrich, RW;Habermann, CJ;Laurent, G
通讯作者：
Laurent, G