Plasma bradykinin levels and urinary kallikrein excretion in normal renin essential hypertension.
Plasma bradykinin levels and urinary kallikrein excretion in normal renin essential hypertension.
复制标题
正常肾素原发性高血压的血浆缓激肽水平和尿激肽释放酶排泄。
DOI：
10.1210/jcem-48-4-642
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
T. Moore
中科院分区：
文献类型：
--
作者：
J. Mersey;G. Williams;R. Emanuel;R. Dluhy;P. Wong;T. Moore
摘要：先前的研究已记录原发性高血压患者尿激肽释放酶排泄低于正常。由于近期有证据表明肾激肽释放酶可促进循环激肽池的形成，因此可以假设激肽释放酶 - 激肽血管舒张系统活性降低可能通过降低全身血管舒张活性而促进这些患者的高血压进程。为了检验这种可能性，对30名高血压患者和21名正常血压受试者的尿激肽释放酶排泄量和血浆激肽水平进行了比较。本研究仅纳入原发性高血压且肾素活性（PRA）水平正常的受试者；高血压组和正常血压组在年龄、性别和种族分布方面相似。受试者在饮食平衡的情况下接受研究，饮食中含10毫当量钠/100毫当量钾/天。肾素活性和激肽水平通过放射免疫分析（RIA）测定，尿激肽释放酶通过αN - P - 甲苯磺酰 - L - 精氨酸甲酯酯酶法测定。与先前的研究一样，发现……
ABSTRACT Previous studies have documented subnormal urinary kallikrein excretion in patients with essential hypertension. Since recent evidence suggests that renal kallikrein can contribute to the circulating kinin pool, it could be hypothesized that decreased activity of the kallikrein-kinin vasodilatory system may contribute to the hypertensive process in these patients by decreasing systemic vasodilator activity. To test this possibility, urinary kallikrein excretion and plasma kinin levels were compared in 30 hypertensive and 21 normotensive subjects. Only subjects with essential hypertension and normal levels of PRA were included in this study; the hypertensive and normotensive groups were similar with regard to age, sex, and race distribution. Subjects were studied in balance on a diet containing 10 meq Na/100 meq K-day. PRA and kinin levels were measured by RIA and urinary kallikrein was measured by the αN-P-tosyl-Larginine-methyl ester esterase method. As in previous studies, it was found that mea...
肾激肽释放酶-激肽系统。
影响因子：
19.6
作者：
Scicli,AG;Carretero,OA
通讯作者：
Carretero,OA