Computational Analysis and Visualization of Spiral Wave Reentry in a Virtual Heart Model
Computational Analysis and Visualization of Spiral Wave Reentry in a Virtual Heart Model
复制标题
虚拟心脏模型中螺旋波折返的计算分析和可视化
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
R. Suzuki
中科院分区：
文献类型：
--
作者：
K. Nakazawa;Tohru Suzuki;T. Ashihara;M. Inagaki;T. Namba;T. Ikeda;R. Suzuki
有研究认为，螺旋波再入是功能性心动过速的主要机制。在这项研究中，我们展示了在虚拟心脏模型中获得的基于螺旋波再入的快节奏兴奋传播动力学图像。为此，我们使用了超级计算机的高性能计算技术和彩色计算机图形的可视化技术。在该心脏模型中，心肌单元由两类非线性常微分方程表示。心肌单元彼此连接成简单形状的二维或三维介质，与心脏壁相对应，也连接成人心室形状的介质。通过在三维图形实现中采用的可视化技术的各种改进，可以清晰地可视化激发传播的动力学。我们的研究结果表明，即使在没有任何传导异常或复极异质性的心脏中，如梗死或缺血，致命性心律失常（通常称为心室颤动）也有可能发生，并导致猝死。
It has been suggested that spiral wave reentry is the principal mechanism of functional tachyarrhythmias. In this study, we present images of the dynamics of tachyarrhythmic excitation propagation based on spiral wave reentry obtained in a virtual heart model. For this purpose, we employed high-performance computation techniques using a supercomputer and visualizing techniques using color computer graphics. In this heart model, the myocardial units were represented by two types of non-linear ordinary differential equations. The myocardial units were connected to each other into simple shaped two-or three-dimensional media corresponding to the heart walls and also into a human ventricular-shaped medium. The dynamics of excitation propagation were visualized intelligibly through various improvements in the visualizing techniques employed in the implementation of the three-dimensional graphics. Our results suggested that it is possible for lethal arrhythmia, commonly called ventricular fibrillation, to occur even in hearts without any conduction abnormalities or repolarization heterogeneity, e.g., infarction or ischemia, and cause sudden death.
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影响因子：
20.1
作者：
LUO, CH;RUDY, Y
通讯作者：
RUDY, Y
乙酰胆碱在离体犬右心房中引起的蜿蜒和不稳定的折返波前。
DOI：
10.1152/ajpheart.1997.273.1.h356
发表时间：
1997
期刊：
The American journal of physiology.
影响因子：
--
作者：
Ikeda,T;Wu,TJ;Uchida,T;Hough,D;Fishbein,MC;Mandel,WJ;Chen,PS;Karagueuzian,HS
通讯作者：
Karagueuzian,HS
在孤立的人体心房组织中诱导蜿蜒的功能性折返波前。
影响因子：
37.8
作者：
Ikeda,T;Czer,L;Trento,A;Hwang,C;Ong,JJ;Hough,D;Fishbein,MC;Mandel,WJ;Karagueuzian,HS;Chen,PS
通讯作者：
Chen,PS
蜿蜒折返波前与心房解剖障碍的附着。
影响因子：
20.1
作者：
Ikeda,T;Yashima,M;Uchida,T;Hough,D;Fishbein,MC;Mandel,WJ;Chen,PS;Karagueuzian,HS
通讯作者：
Karagueuzian,HS