MicroRNAs in mouse development and disease.

MicroRNAs in mouse development and disease.
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DOI:
10.1016/j.semcdb.2010.02.004
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发表时间:
2010-09
影响因子:
7.3
通讯作者:
Steel, Karen P.
Steel, Karen P.
中科院分区:
生物学2区
文献类型:
--
作者:
Lewis, Morag A.;Steel, Karen P.

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MicroRNA是一种小的非编码RNA,作为靶基因的阻遏物,于1993年被发现,此后已被证明在许多系统的发展中发挥重要作用。与这种作用相一致,它们也涉及多种疾病的发病机制。在这里,我们回顾了microRNA在小鼠发育和疾病中的参与,特别是以耳聋为例。
MicroRNAs, small non-coding RNAs which act as repressors of target genes, were discovered in 1993, and since then have been shown to play important roles in the development of numerous systems. Consistent with this role, they are also implicated in the pathogenesis of multiple diseases. Here we review the involvement of microRNAs in mouse development and disease, with particular reference to deafness as an example.
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