The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm.
The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm.
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DOI：
10.1016/j.neuroimage.2012.12.055
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发表时间：
2013-04-15
期刊：
影响因子：
5.7
通讯作者：
Lukas, Scott E.
中科院分区：
文献类型：
--
作者：
Licata, Stephanie C.;Nickerson, Lisa D.;Lowen, Steven B.;Trksak, George H.;MacLean, Robert R.;Lukas, Scott E.
脑区域的网络具有同步波动的血氧水平依赖功能磁共振成像（BOLD fMRI）的时间序列在休息，或“静息状态网络”（rsn），正在成为理解内在的大脑活动的基础。rsn在地形上与服务于感觉、运动和认知过程的活动相关网络一致，研究它们在急性药物刺激后的自发波动可能为更好地理解药物作用的神经解剖学基础提供了一种方法。本研究采用3T时BOLD功能磁共振成像（fMRI）研究非苯二氮卓类催眠药物唑吡坦（Ambien®）对功能网络的影响。唑吡坦是γ-氨基丁酸（GABAA）受体的积极调节剂，并产生镇静作用，这可能部分解释了它如何调节内在的大脑活动。健康参与者（n= 12）在急性口服唑吡坦（0,5,10或20mg） 45分钟后进行fMRI扫描，并在参与者凝视静态固定点（即静止）时测量BOLD信号的变化。使用双回归的组独立成分分析（ICA）对数据进行分析，结果表明，与安慰剂相比，最高剂量的唑吡坦增加了许多感觉、运动和边缘网络的功能连通性。这些结果与先前的研究结果一致，表明服用阳性GABAA受体调节剂咪达唑仑和酒精后，休息时功能连通性增加，并表明研究唑吡坦如何调节内在脑活动可能有助于了解其强大镇静作用的病因。
Networks of brain regions having synchronized fluctuations of the blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) time-series at rest, or “resting state networks” (RSNs), are emerging as a basis for understanding intrinsic brain activity. RSNs are topographically consistent with activity-related networks subserving sensory, motor, and cognitive processes, and studying their spontaneous fluctuations following acute drug challenge may provide a way to understand better the neuroanatomical substrates of drug action. The present within-subject double-blind study used BOLD fMRI at 3T to investigate the functional networks influenced by the non-benzodiazepine hypnotic zolpidem (Ambien®). Zolpidem is a positive modulator of γ-aminobutyric acidA (GABAA) receptors, and engenders sedative effects that may be explained in part by how it modulates intrinsic brain activity. Healthy participants (n= 12) underwent fMRI scanning 45 min after acute oral administration of zolpidem (0, 5, 10, or 20 mg), and changes in BOLD signal were measured while participants gazed at a static fixation point (i.e., at rest). Data were analyzed using group independent component analysis (ICA) with dual regression and results indicated that compared to placebo, the highest dose of zolpidem increased functional connectivity within a number of sensory, motor, and limbic networks. These results are consistent with previous studies showing an increase in functional connectivity at rest following administration of the positive GABAA receptor modulators midazolam and alcohol, and suggest that investigating how zolpidem modulates intrinsic brain activity may have implications for understanding the etiology of its powerful sedative effects.
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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