Prognostic Significance of Preoperative and Postoperative Complement C3 Depletion in Gastric Cancer: A Three-Year Survival Investigation.
Prognostic Significance of Preoperative and Postoperative Complement C3 Depletion in Gastric Cancer: A Three-Year Survival Investigation.
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胃癌术前和术后补体 C3 消耗的预后意义：三年生存调查
DOI：
10.1155/2017/2161840
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发表时间：
2017
影响因子：
--
通讯作者：
He Y
中科院分区：
文献类型：
--
作者：
Ye J;Ren Y;Chen J;Song W;Chen C;Cai S;Tan M;Yuan Y;He Y
补体系统在胃癌预后预测中的作用尚不清楚。本研究旨在探讨GC患者补体C3耗竭的发生率和相关结局。 前瞻性分析了2013年8月至2013年12月期间106例胃腺癌患者。分别在基线、手术前1天和术后第3天检测血浆补体C3和C4水平。具有低C3水平（<0.75 mg/mL）的患者被认为具有补体耗竭（CD），而具有正常C3水平的其他患者被包括作为对照。比较两组患者的3年总生存期（OS）、无病生存期（DFS）等预后，同时探讨CD的发生率。 术前CD发生率为28.3%，术后增加至37.7%。术前CD与住院时间延长（22.7 vs 19.2天，P = 0.032）、术后并发症增加（33.3% vs 14.5%，P = 0.030）和住院费用增加（P = 0.013）相关。此外，术后C3耗竭与3年OS（P = 0.022）和DFS（P = 0.003）降低显著相关。术后C3耗竭和肿瘤分期是预后不良的独立预测因素。 胃癌中发生的补体C3耗竭与不良的短期和长期结局相关。
The role of complement system in predicting prognosis of gastric cancer (GC) remains obscured. This study aims to explore the incidence of complement C3 depletion and associated outcomes in GC patients. between August 2013 and December 2013, 106 patients with gastric adenocarcinoma were prospectively analyzed. Plasma levels of complement C3 and C4 were detected at baseline, one day before surgery, and postoperative day 3, respectively. Patients with low C3 levels (<0.75 mg/mL) were considered as having complement depletion (CD), while others with normal C3 levels were included as control. The 3-year overall survival (OS), disease-free survival (DFS), and other outcomes were compared between both groups, with the CD incidence explored meanwhile. The CD incidence was 28.3% before surgery but increased to 37.7% after surgery. Preoperative CD was related to prolonged hospital stay (22.7 versus 19.2 day, P = 0.032) and increased postoperative complications (33.3% versus 14.5%, P = 0.030) and hospital costs (P = 0.013). Besides, postoperative C3 depletion was significantly associated with decreased 3-year OS (P = 0.022) and DFS (P = 0.003). Moreover, postoperative C3 depletion and advanced tumor stage were independent predictive factors of poor prognosis. Complement C3 depletion occurring in gastric cancer was associated with poor short-term and long-term outcomes.
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影响因子：
3.7
作者：
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通讯作者：
Li J
影响因子：
6.4
作者：
Wilczek, Ewa;Rzepko, Robert;Wilczynski, Grzegorz M.
通讯作者：
Wilczynski, Grzegorz M.
影响因子：
3.7
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影响因子：
158.5
作者：
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通讯作者：
Schlemper, RJ