Increased serum lysyl oxidase-like 2 levels correlate with the degree of left atrial fibrosis in patients with atrial fibrillation
Increased serum lysyl oxidase-like 2 levels correlate with the degree of left atrial fibrosis in patients with atrial fibrillation
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心房颤动患者血清赖氨酰氧化酶样2水平升高与左心房纤维化程度相关
DOI：
10.1042/bsr20171332
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发表时间：
2017-10
影响因子：
4
通讯作者：
Li Dianfu
中科院分区：
文献类型：
--
作者：
Zhao yingming;Tang kangting;Xu Tianbao;Wang Junhong;Yang Jin;Li Dianfu
心房颤动（AF）进展通常伴随着心房纤维化和心房结构重塑的增加。已知赖氨酰氧化酶样 2 (LOXL2) 在许多纤维化病症（包括心脏纤维化）中发挥重要作用。本研究旨在探讨血清LOXL2水平与房颤的关系。 54 名 AF 患者和 32 名对照受试者参加了该研究。进行高密度三维电解剖测绘，并评估 AF 患者的平均双极电压。 LOXL2水平通过酶联免疫吸附测定法测量。所有患者均接受超声心动图检查以评估左心房大小和左心室功能。与对照组相比，AF患者血清LOXL2水平显着升高（526.81±316.82 vs 240.94±92.51 pg/ml，P<0.01）。此外，血清LOXL2水平与左心房（LAD）大小显着相关（r2=0.38，P<0.01）。此外，LAD≥40mm的AF患者血清LOXL2水平显着高于LAD<40mm的AF患者（664.34±346.50 vs 354.90±156.23pg/ml，P<0.01）。 Spearman相关分析进一步显示，AF患者的平均双极左心房电压与LOXL2呈负相关（r2=-0.49，P<0.01）。多变量回归分析进一步表明，血清LOXL2[优势比（OR）1.013，95%置信区间（CI）1.002-1.024，P<0.05]和LAD（OR 1.704，95%CI 1.131-2.568，P<0.01）是AF的独立预测因子。总之，AF患者血清LOXL2水平显着升高，且与左心房纤维化程度相关。
Atrial fibrillation (AF) progression is generally accompanied by increased atrial fibrosis and atrial structural remodeling. Lysyl oxidase-like 2 (LOXL2) is known to play an important role in many fibrotic conditions, including cardiac fibrosis. The present study aimed to explore the relationship between serum LOXL2 levels and AF. Fifty-four AF patients and 32 control subjects were enrolled in the study. High-density three-dimensional electroanatomic mapping was performed, and mean bipolar voltage was assessed in AF patients. LOXL2 levels were measured by enzyme-linked immunosorbent assay. All patients underwent echocardiography to assess left atrium size and left ventricle function. Serum LOXL2 levels were significantly elevated in AF patients compared with the control group (526.81 ± 316.82 vs 240.94 ± 92.51 pg/ml, P<0.01). In addition, serum LOXL2 level was significantly correlated with the size of the left atrium (LAD) (r2 = 0.38, P<0.01). Furthermore, the serum LOXL2 levels were significantly higher in AF patients with LAD ≥ 40 mm compared with those with LAD < 40 mm (664.34 ± 346.50 vs 354.90 ± 156.23 pg/ml, P<0.01). And the Spearman’s correlation analysis further revealed that the mean bipolar left atrial voltage was inversely correlated with the LOXL2 (r2 = −0.49, P<0.01) in AF patients. Multivariate regression analysis further demonstrated that serum LOXL2 [odds ratio (OR) 1.013, 95% confidence interval (CI) 1.002–1.024, P<0.05] and LAD (OR 1.704, 95% CI 1.131–2.568, P<0.01) were independent predictors of AF. In conclusion, serum LOXL2 levels were significantly elevated and were correlated with the degree of left atrial fibrosis in AF patients.
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DOI：
10.1016/s0021-9258(18)67681-1
发表时间：
1986-07
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
P. Williamson;H. Kagan
通讯作者：
P. Williamson;H. Kagan
DOI：
10.1086/653481
发表时间：
2010-08-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Soares MB;de Lima RS;Rocha LL;Vasconcelos JF;Rogatto SR;dos Santos RR;Iacobas S;Goldenberg RC;Iacobas DA;Tanowitz HB;de Carvalho AC;Spray DC
通讯作者：
Spray DC
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
37.8
作者：
January CT;Wann LS;Alpert JS;Calkins H;Cigarroa JE;Cleveland JC Jr;Conti JB;Ellinor PT;Ezekowitz MD;Field ME;Murray KT;Sacco RL;Stevenson WG;Tchou PJ;Tracy CM;Yancy CW;ACC/AHA Task Force Members
通讯作者：
ACC/AHA Task Force Members
影响因子：
37.8
作者：
Yancy, Clyde W.;Jessup, Mariell;Westlake, Cheryl
通讯作者：
Westlake, Cheryl