Vitamin D status: effects on parathyroid hormone and 1, 25-dihydroxyvitamin D in postmenopausal women.
Vitamin D status: effects on parathyroid hormone and 1, 25-dihydroxyvitamin D in postmenopausal women.
复制标题
维生素 D 状态：对绝经后妇女甲状旁腺激素和 1, 25-二羟基维生素 D 的影响。
DOI：
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发表时间：
2000
影响因子：
7.1
通讯作者：
B. Nordin
中科院分区：
文献类型：
--
作者：
A. Need;M. Horowitz;H. Morris;B. Nordin
背景
低血清25-羟基维生素D <$25（OH）D浓度常见于老年人，并与髋部骨折有关。维生素D和钙的治疗可以降低骨折的风险。甲状旁腺激素（PTH）随年龄增长而升高与25（OH）D降低之间的关系尚不清楚。对于骨骼健康所需的25（OH）D血清浓度也没有任何共识。
目的
我们的目的是研究绝经后妇女血清甲状旁腺素、血清维生素D代谢产物和其他钙相关变量之间的关系。
设计
这是一项对496名绝经后骨质疏松症门诊就诊的无椎骨骨折的绝经后妇女的横断面研究。
结果
PTH与年龄、血清1，25-二羟维生素D <$1，25（OH）（2）D呈显著正相关，与25（OH）D、血浆离子钙呈显著负相关。当血清25（OH）D降至40 nmol/L以下时，PTH呈阶梯状升高。在25（OH）D浓度>40 nmol/L的女性中，1，25（OH）（2）D与25（OH）D呈正相关;在25（OH）D浓度</=40 nmol/L的女性中，关系相反。在25（OH）D浓度</=40 nmol/L的女性中，1，25（OH）（2）D与PTH最密切相关;在25（OH）D浓度>40 nmol/L的女性中，1，25（OH）（2）D与血浆肌酐最密切（负）相关。因此，随着血清25（OH）D浓度逐渐<40 nmol/L，血清1，25（OH）（2）D变得严重依赖于PTH浓度的升高。
结论
数据表明，老年妇女应保持25（OH）D浓度>40 nmol/L（这是我们对健康年轻受试者的正常范围的下限），以获得最佳的骨骼健康。
BACKGROUND
Low serum 25-hydroxyvitamin D ¿25(OH)D concentrations are commonly found in the elderly and are associated with hip fracture. Treatment with vitamin D and calcium can reduce the risk of fracture. The relation between the rise in parathyroid hormone (PTH) with age and the decrease in 25(OH)D is not clear. Neither is there any consensus on the serum concentration of 25(OH)D required for bone health.
OBJECTIVE
Our objective was to study the relations between serum PTH, serum vitamin D metabolites, and other calcium-related variables in postmenopausal women.
DESIGN
This was a cross-sectional study of 496 postmenopausal women without vertebral fractures attending our menopausal osteoporosis clinics.
RESULTS
PTH was significantly positively related to age and serum 1, 25-dihydroxyvitamin D ¿1,25(OH)(2)D and inversely related to 25(OH)D and plasma ionized calcium. There was a step-like increase in PTH as serum 25(OH)D fell below 40 nmol/L. In women with 25(OH)D concentrations >40 nmol/L, 1,25(OH)(2)D was positively related to 25(OH)D; in women with 25(OH)D concentrations </=40 nmol/L, the relation was the inverse. In women with 25(OH)D concentrations </=40 nmol/L, 1,25(OH)(2)D was most closely related to PTH; in women with 25(OH)D concentrations >40 nmol/L, 1,25(OH)(2)D was most closely (inversely) related to plasma creatinine. Therefore, with serum 25(OH)D concentrations increasingly <40 nmol/L, serum 1,25(OH)(2)D becomes critically dependent on rising concentrations of PTH.
CONCLUSION
The data suggest that aging women should maintain 25(OH)D concentrations >40 nmol/L (which is the lower limit of our normal range for healthy young subjects) for optimal bone health.
影响因子：
120.7
作者：
LeBoff, MS;Kohlmeier, L;Glowacki, J
通讯作者：
Glowacki, J
随着女性年龄的增长，维生素 D 代谢受损。
DOI：
10.1172/jci111373
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Tsai,KS;Heath3rd,H;Kumar,R;Riggs,BL
通讯作者：
Riggs,BL
影响因子：
7.1
作者：
Kinyamu, HK;Gallagher, JC;Balhorn, KE
通讯作者：
Balhorn, KE