Role of ferroptosis in neurological diseases

Role of ferroptosis in neurological diseases
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铁死亡在神经系统疾病中的作用

DOI:
10.1016/j.neulet.2020.135614
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发表时间:
2021-01
影响因子:
2.5
通讯作者:
Gao Jing
Gao Jing
中科院分区:
医学4区
文献类型:
--
作者:
Yao Min-Yi;Liu Tao;Zhang Liang;Wang Ming-Jian;Yang Yong;Gao Jing

文献摘要

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铁凋亡是一种新发现的非凋亡调节细胞死亡(RCD)形式,其特征是铁依赖性脂质过氧化物的积累,导致氧化应激和细胞死亡。近年来的研究表明,铁下垂在脑出血、缺血性中风、癫痫、神经退行性疾病、创伤性脑损伤和脑癌等神经系统疾病的病理中起着重要作用。本文综述了近年来有关铁下垂与神经系统疾病关系的最新研究进展,重点介绍了铁下垂的机制,并阐述了神经系统疾病治疗的新前景。
Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD) characterized by iron-dependent accumulation of lipid peroxides which leads to oxidative stress and cell death. Recent studies have indicated that ferroptosis plays an essential role in the pathology of neurological diseases, such as intracerebral hemorrhage, ischemic stroke, epilepsy, neurodegenerative diseases, traumatic brain injury and brain cancer. This review focuses on the latest researches on the relationship of ferroptosis with nervous system diseases, highlighting the ferroptosis-based mechanisms, and elaborating the new perspective therapeutic targets of neurological disorders.
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