Dietary intake of nitrate and nitrite and risk of renal cell carcinoma in the NIH-AARP Diet and Health Study.
Dietary intake of nitrate and nitrite and risk of renal cell carcinoma in the NIH-AARP Diet and Health Study.
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DOI：
10.1038/bjc.2012.522
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发表时间：
2013-01-15
影响因子：
8.8
通讯作者：
Ward, M. H.
中科院分区：
文献类型：
--
作者：
DellaValle, C. T.;Daniel, C. R.;Aschebrook-Kilfoy, B.;Hollenbeck, A. R.;Cross, A. J.;Sinha, R.;Ward, M. H.
硝酸盐和亚硝酸盐存在于许多食物中，是n -亚硝基化合物的前体，是已知的动物致癌物和潜在的人类致癌物。在美国国立卫生研究院-美国退休人员协会的饮食与健康研究中，我们前瞻性地调查了饮食来源的硝酸盐和亚硝酸盐摄入量与肾细胞癌（RCC）总体、透明细胞和乳头状组织学亚型风险之间的关系。硝酸盐和亚硝酸盐的摄入量是通过一份包含124个项目的食物频率问卷来估算的。在平均9年的随访中，我们在49841名参与者中发现了1816例RCC病例（n=498，透明细胞；n=115，乳头状细胞）。采用Cox比例风险回归估计风险比（hr）和95%置信区间（ci）。动物源亚硝酸盐摄入量最高的五分之一个体与最低的五分之一个体相比，总RCC和透明细胞亚型的风险增加（HR=1.28, 95% CI, 1.10-1.49， HR=1.68, 95% CI, 1.25-2.27）。加工肉类和其他动物来源的亚硝酸盐与透明细胞腺癌风险增加相关（HR=1.33, 95% CI, 1.01-1.76， HR=1.78, 95% CI, 1.34-2.36）。我们没有发现从植物来源摄入亚硝酸盐和总体摄入硝酸盐之间的联系。我们的研究结果表明，动物来源的亚硝酸盐可能会增加RCC的风险，特别是透明细胞腺癌。
Nitrate and nitrite are present in many foods and are precursors of N-nitroso compounds, known animal carcinogens and potential human carcinogens. We prospectively investigated the association between nitrate and nitrite intake from dietary sources and risk of renal cell carcinoma (RCC) overall and clear cell and papillary histological subtypes in the NIH-AARP Diet and Health Study. Nitrate and nitrite intakes were estimated from a 124-item food frequency questionnaire. Over a mean follow-up of 9 years, we identified 1816 RCC cases (n=498, clear cell; n=115, papillary cell) among 491 841 participants. Cox proportional hazard regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Individuals in the highest quintile of nitrite intake from animal sources compared with those in the lowest quintile, had an increased risk of total RCC and clear cell subtype (HR=1.28, 95% CI, 1.10–1.49 and HR=1.68, 95% CI, 1.25–2.27, respectively). Nitrite from processed meats and other animal sources were associated with increased clear cell adenocarcinoma risk (HR=1.33, 95% CI, 1.01–1.76 and HR=1.78, 95% CI, 1.34–2.36, respectively). We found no association for nitrite intake from plant sources or nitrate intake overall. Our findings suggest that nitrite from animal sources may increase the risk of RCC, particularly clear cell adenocarcinomas.
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DOI：
10.1016/0926-6917(94)90022-1
发表时间：
1994-11-01
期刊：
EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION
影响因子：
--
作者：
GANGOLLI, SD;VANDENBRANDT, PA;WISHNOK, JS
通讯作者：
WISHNOK, JS
DOI：
10.1016/0027-5107(88)90194-7
发表时间：
1988-12-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
BARTSCH, H;OHSHIMA, H;PIGNATELLI, B
通讯作者：
PIGNATELLI, B
影响因子：
7.7
作者：
CHILVERS, C;INSKIP, H;HILL, M
通讯作者：
HILL, M
影响因子：
1.5
作者：
Hard, GC
通讯作者：
Hard, GC
影响因子：
6.4
作者：
Kilfoy, Briseis A.;Zhang, Yawei;Park, Yikyung;Holford, Theodore R.;Schatzkin, Arthur;Hollenbeck, Albert;Ward, Mary H.
通讯作者：
Ward, Mary H.