Dietary nitrate and nitrite and the risk of thyroid cancer in the NIH-AARP Diet and Health Study.
Dietary nitrate and nitrite and the risk of thyroid cancer in the NIH-AARP Diet and Health Study.
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DOI：
10.1002/ijc.25650
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发表时间：
2011-07-01
影响因子：
6.4
通讯作者：
Ward, Mary H.
中科院分区：
文献类型：
--
作者：
Kilfoy, Briseis A.;Zhang, Yawei;Park, Yikyung;Holford, Theodore R.;Schatzkin, Arthur;Hollenbeck, Albert;Ward, Mary H.
在过去的几十年里，全世界范围内观察到甲状腺癌的发病率不断增加。硝酸盐抑制甲状腺对碘的吸收，可能破坏甲状腺功能。最近在爱荷华州对老年妇女进行的一项队列研究中报告了与硝酸盐摄入相关的甲状腺癌风险增加。我们在美国国立卫生研究院-美国退休人员协会（NIH-AARP）饮食与健康研究中评估了饮食中硝酸盐和亚硝酸盐摄入量与甲状腺癌的总体风险和亚型风险，该研究是一项大型前瞻性队列研究，包括490，194名男性和女性，年龄在1995-1996年，50-71岁。饮食摄入量采用124项食物频率问卷进行评估。在平均7年的随访中，我们确定了370例甲状腺癌病例（170例男性，200例女性），并提供了完整的饮食信息。在男性中，硝酸盐摄入量的增加与甲状腺癌风险呈正相关（最高五分位数与最低五分位数的相对风险（RR）=2.28，95% CI：1.29-4.04l; p趋势<0.001）;然而，我们没有观察到女性摄入量的趋势（p趋势=0.61）。亚硝酸盐摄入量与男性或女性患甲状腺癌的风险无关。我们评估了两种主要类型甲状腺癌的风险。我们发现硝酸盐摄入与男性乳头状癌（RR = 2.10; 95%CI：1.09-4.05; p-trend=0.05）和滤泡状甲状腺癌（RR= 3.42; 95%CI：1.03-11.4; p-trend=0.01）呈正相关。男性亚硝酸盐摄入量与滤泡性甲状腺癌风险增加相关（RR= 2.74; 95%CI：0.86-8.77; p趋势=0.04）。我们的研究结果支持硝酸盐在甲状腺癌风险中的作用，并建议进一步研究这些暴露是必要的。
During the past several decades, an increasing incidence of thyroid cancer has been observed worldwide. Nitrate inhibits iodide uptake by the thyroid, potentially disrupting thyroid function. An increased risk of thyroid cancer associated with nitrate intake was recently reported in a cohort study of older women in Iowa. We evaluated dietary nitrate and nitrite intake and thyroid cancer risk overall and for subtypes in the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study, a large prospective cohort of 490,194 men and women, ages 50–71 years in 1995–1996. Dietary intakes were assessed using a 124-item food frequency questionnaire. During an average of 7 years of follow-up we identified 370 incident thyroid cancer cases (170 men, 200 women) with complete dietary information. Among men, increasing nitrate intake was positively associated with thyroid cancer risk (relative risk (RR) for the highest quintile versus lowest quintile RR=2.28, 95% CI: 1.29–4.04l; p-trend <0.001); however, we observed no trend with intake among women (p-trend=0.61). Nitrite intake was not associated with risk of thyroid cancer for either men or women. We evaluated risk for the two main types of thyroid cancer. We found positive associations for nitrate intake and both papillary (RR = 2.10; 95%CI: 1.09–4.05; p-trend=0.05) and follicular thyroid cancer (RR= 3.42; 95%CI: 1.03–11.4; p-trend=0.01) among men. Nitrite intake was associated with increased risk of follicular thyroid cancer (RR= 2.74; 95%CI: 0.86–8.77; p-trend=0.04) among men. Our results support a role of nitrate in thyroid cancer risk and suggest that further studies to investigate these exposures are warranted.
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影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
7.1
作者：
George, Stephanie M.;Park, Yikyung;Subar, Amy F.
通讯作者：
Subar, Amy F.
DOI：
10.1016/0926-6917(94)90022-1
发表时间：
1994-11-01
期刊：
EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION
影响因子：
--
作者：
GANGOLLI, SD;VANDENBRANDT, PA;WISHNOK, JS
通讯作者：
WISHNOK, JS
影响因子：
7.7
作者：
CHILVERS, C;INSKIP, H;HILL, M
通讯作者：
HILL, M
影响因子：
64.8
作者：
BOYLAND, E;WALKER, SA
通讯作者：
WALKER, SA