Clinical and demographic factors contributing to asparaginase-associated toxicities in children with acute lymphoblastic leukemia.
Clinical and demographic factors contributing to asparaginase-associated toxicities in children with acute lymphoblastic leukemia.
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DOI：
10.1080/10428194.2022.2102621
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发表时间：
2022-12
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
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作者：
共审查了548例诊断为急性淋巴细胞白血病的患者（年龄范围：1-22岁，60.4%为西班牙裔，55.8%为男性）的培门冬酯相关超敏反应（14.8%）、高胆红素血症（9.7%）、静脉血栓栓塞（VTE，9.7%）和胰腺炎（5.3%）。比值比（OR）和95%置信区间（CI）评估了临床因素与每种毒性、累积毒性数量和使用k-模式分析确定的毒性簇之间的相关性。大多数（68.9%）未发生任何毒性，24.6%发生一次毒性，6.3%发生两次或两次以上毒性。年龄>10岁与高胆红素血症有关（OR = 3.83; 95%CI：1.64-8.95），胰腺炎（OR = 3.72; 95% CI：1.29-10.68），VTE（OR = 4.65; 95%CI：1.96-11.02），累积毒性负荷（OR = 3.28，95%CI：1.97-5.47）;高危治疗伴超敏反应（OR 2.25，95%CI：1.25-4.05）;超重伴累积毒性负荷（OR = 1.76，95%CI：1.20-2.57）。确定了8种独特的毒性特征。年龄较大、超重和治疗强度导致了哌醋甲酯相关毒性。
A total of 548 patients (age range: 1–22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pegaspargase-associated hypersensitivity (14.8%), hyperbilirubinemia (9.7%), venous thromboembolism (VTE, 9.7%), and pancreatitis (5.3%). Odds ratios (OR) and 95% confidence intervals (CI) evaluated associations between clinical factors and each toxicity, cumulative number of toxicities, and toxicity clusters identified using k-mode analysis. Most (68.9%) did not experience any toxicity, 24.6% experienced one toxicity, and 6.3% two or more. Age >10 years was associated with hyperbilirubinemia (OR = 3.83; 95% CI: 1.64–8.95), pancreatitis (OR = 3.72; 95% CI: 1.29–10.68), VTE (OR = 4.65; 95% CI: 1.96–11.02), and cumulative toxicity burden (OR = 3.28, 95% CI: 1.97–5.47); high-risk therapy with hypersensitivity (OR 2.25; 95% CI 1.25–4.05); and overweight with cumulative toxicity burden (OR = 1.76, 95% CI: 1.20–2.57). Eight unique toxicity profiles were identified. Older age, overweight, and treatment intensity contribute to pegaspargase-associated toxicities.
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影响因子：
6.7
作者：
Liu Y;Fernandez CA;Smith C;Yang W;Cheng C;Panetta JC;Kornegay N;Liu C;Ramsey LB;Karol SE;Janke LJ;Larsen EC;Winick N;Carroll WL;Loh ML;Raetz EA;Hunger SP;Devidas M;Yang JJ;Mullighan CG;Zhang J;Evans WE;Jeha S;Pui CH;Relling MV
通讯作者：
Relling MV
DOI：
10.1158/1055-9965.epi-19-0941
发表时间：
2020-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
通讯作者：
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影响因子：
5.8
作者：
Dinndorf, Patricia Anne;Gootenberg, Joseph;Pazdur, Richard
通讯作者：
Pazdur, Richard
影响因子：
45.3
作者：
Angiolillo, Anne L.;Schore, Reuven J.;Hunger, Stephen P.
通讯作者：
Hunger, Stephen P.
影响因子：
45.3
作者：
Gupta, Sumit;Wang, Cindy;Devidas, Meenakshi
通讯作者：
Devidas, Meenakshi