Cancer Progress and Priorities: Childhood Cancer.
Cancer Progress and Priorities: Childhood Cancer.
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DOI：
10.1158/1055-9965.epi-19-0941
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
据估计，全世界每年有30万0-14岁的儿童被诊断患有癌症。虽然儿童患癌症的绝对风险很低，但在高收入国家，它是儿童因疾病死亡的主要原因。尽管如此，儿童癌症的病因在很大程度上还是未知的。我们回顾了儿童癌症流行病学的几个组成部分的文献，包括发病率、生存率、危险因素、病因异质性和预防。在描述了儿童癌症流行病学的已知模式之后，我们提出了流行病学研究的未来方向。最近的研究表明，全世界儿童癌症的发病率被低估了，特别是在中低收入国家。虽然生存状况持续改善，但全球存在着显著差异。在危险因素方面，有一些确定的关联包括种族/民族、出生体重、出生缺陷和电离辐射。确定新的风险因素对未来的预防工作至关重要。未来儿童癌症的流行病学研究应纳入新的暴露方法、肿瘤的分子特征和更完整的基因-环境相互作用评估。希望我们对儿童癌症病因的理解能够更好地确定，从而产生新的监测或预防策略。
It is estimated that 300,000 children 0-14 years of age are diagnosed with cancer worldwide each year. While the absolute risk of cancer in children is low, in high-income countries, it is the leading cause of death due to disease in children. In spite of this, the etiologies of childhood cancer are largely unknown. We reviewed the literature on several components of the epidemiology of childhood cancer, including incidence, survival, risk factors, etiologic heterogeneity, and prevention. After describing known patterns in the epidemiology of childhood cancer, we propose future directions for epidemiologic research. Recent studies indicate the worldwide incidence of childhood cancer is underestimated, especially in middle- and low-income countries. While survival continues to improve, there are significant disparities across the globe. In terms of risk factors, there are a few well-established associations including race/ethnicity, birthweight, birth defects, and ionizing radiation. Identifying novel risk factors is imperative for future prevention efforts. Future epidemiologic studies of childhood cancer should incorporate novel exposure methodologies, molecular features of tumors, and a more complete assessment of gene-environment interactions. It is hoped that our understanding of the causes of childhood cancer can be better ascertained, leading to novel surveillance or prevention strategies.
影响因子：
4.5
作者：
Dockerty JD;Herbison P;Skegg DC;Elwood M
通讯作者：
Elwood M
影响因子：
3.2
作者：
Lupo, Philip J.;Lee, Laura J.;Okcu, M. Fatih;Bondy, Melissa L.;Scheurer, Michael E.
通讯作者：
Scheurer, Michael E.
影响因子：
3.2
作者：
Spector, Logan G.;Ross, Julie A.;Olshan, Andrew F.
通讯作者：
Olshan, Andrew F.