Age-related composition changes in swallowing-related muscles: a Dixon MRI study
Age-related composition changes in swallowing-related muscles: a Dixon MRI study
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吞咽相关肌肉的年龄相关成分变化：迪克森 MRI 研究
DOI：
10.1007/s40520-021-01859-2
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发表时间：
2021
影响因子：
4
通讯作者：
K. Domen
中科院分区：
文献类型：
--
作者：
Yuta Nakao;Y. Uchiyama;Kosuke Honda;T. Yamashita;Shota Saito;K. Domen
在超老龄化社会中，吞咽困难被认为是一个社会问题。然而，与吞咽相关的肌肉的年龄相关变化尚未完全破译。我们的目的是在磁共振成像（MRI）上识别多个吞咽相关肌肉中的肌内脂肪浸润和肌肉萎缩。此外，检查了用于评估吞咽相关肌肉质量的适当肌肉强度参数。我们分析了20名老年人和20名年轻人的狄克逊MRI结果，他们没有头颈癌、中风、神经肌肉疾病或全身肌肉减少症，以评估舌、颏舌骨和咽肌的肌内脂肪浸润（IMF）和瘦肌肉质量（LMM）。还评估了咽腔尺寸。在MRI前后一周内评估舌压、开颌力、咬合力和抬头力。年龄显著影响吞咽相关肌肉的IMF，舌肌受影响最大，其次是咽肌，然后是颏舌骨肌。只有颏舌骨肌的LMM随增龄显著降低。老年人和年轻人的咽腔大小没有显著差异，只有舌压与舌、颏舌骨肌和咽肌质量显著相关。IMF主要与吞咽相关肌肉中与年龄相关的组成变化相关，并且通常在舌和咽肌中观察到。颏舌骨肌更容易发生肌肉萎缩而不是脂肪浸润。此外，舌压可以作为评估吞咽相关肌肉质量的参数。
Dysphagia is considered a social problem in the super-aging society. However, age-related changes in swallowing-related muscles have not been fully deciphered. We aimed to identify intramuscular fatty infiltration and muscle atrophy in multiple swallowing-related muscles on magnetic resonance imaging (MRI). Moreover, an appropriate muscle strength parameter for the evaluation of swallowing-related muscle mass was examined. We analyzed the Dixon MRI results of 20 elderly and 20 young adults without head and neck cancer, stroke, neuromuscular disease, or whole-body sarcopenia to evaluate intramuscular fatty infiltration (IMF) and lean muscle mass (LMM) in the tongue, geniohyoid, and pharyngeal muscles. The pharyngeal lumen size was also assessed. Tongue pressure, jaw-opening strength, occlusal force, and head-lifting strength were evaluated within a week before and after MRI. Aging significantly affected the IMF of the swallowing-related muscles, and the tongue muscle was most affected, followed by the pharyngeal muscle and then the geniohyoid muscle. Only the LMM of the geniohyoid muscle significantly decreased with aging. The pharyngeal lumen size did not significantly differ between the elderly and young participants, and only tongue pressure was significantly correlated with tongue, geniohyoid, and pharyngeal muscle mass. IMF is primarily associated with age-related composition changes in swallowing-related muscles, and it is commonly observed in the tongue and pharyngeal muscles. The geniohyoid muscle is more at risk of muscle atrophy rather than fatty infiltration. In addition, tongue pressure can be a parameter for the evaluation of swallowing-related muscle mass.
DOI：
10.1093/gerona/61.10.1059
发表时间：
2006-10-01
影响因子：
5.1
作者：
Goodpaster, Bret H.;Park, Seok Won;Newman, Anne B.
通讯作者：
Newman, Anne B.