Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.
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DOI：
10.1038/ncb3434
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发表时间：
2016-12
影响因子：
21.3
通讯作者：
Behrens A
中科院分区：
文献类型：
--
作者：
Blaas L;Pucci F;Messal HA;Andersson AB;Josue Ruiz E;Gerling M;Douagi I;Spencer-Dene B;Musch A;Mitter R;Bhaw L;Stone R;Bornhorst D;Sesay AK;Jonkers J;Stamp G;Malanchi I;Toftgård R;Behrens A
乳腺是由一个复杂的细胞层次与不寻常的产后可塑性。干/祖细胞群的身份，以及引起乳腺癌的肿瘤起始细胞，是不完全理解的。在这里，我们表明，LGR 6标志着罕见的细胞群体在基底和腔乳腺室的小鼠。谱系追踪分析表明，Lgr 6+细胞是单能祖细胞，在青春期克隆扩增，但在成年期减少。在怀孕期间或卵巢激素刺激后，成年Lgr 6+细胞恢复增殖能力，其后代在重复怀孕期间形成肺泡。Lgr 6+细胞中的致癌突变导致管腔细胞的扩增，最终导致乳腺肿瘤。相反，在乳腺肿瘤发生的MMTV-PyMT模型中，Lgr 6+细胞的耗竭显著损害了肿瘤生长。因此，Lgr 6标记可以引发肿瘤的乳腺祖细胞，以及有效维持肿瘤所需的管腔乳腺肿瘤细胞。
The mammary gland is composed of a complex cellular hierarchy with unusual postnatal plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells that give rise to breast cancer, are incompletely understood. Here we show that Lgr6 marks rare populations of cells in both basal and luminal mammary gland compartments in mice. Lineage tracing analysis showed that Lgr6+ cells are unipotent progenitors, which expand clonally during puberty but diminish in adulthood. In pregnancy or upon stimulation with ovarian hormones, adult Lgr6+ cells regained proliferative potency and their progeny formed alveoli over repeated pregnancies. Oncogenic mutations in Lgr6+ cells resulted in expansion of luminal cells, culminating in mammary gland tumours. Conversely, depletion of Lgr6+ cells in the MMTV-PyMT model of mammary tumourigenesis significantly impaired tumour growth. Thus, Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
宇宙（癌症中的体细胞突变目录）数据库和网站。
影响因子：
8.8
作者：
Bamford, S;Dawson, E;Forbes, S;Clements, J;Pettett, R;Dogan, A;Flanagan, A;Teague, J;Futreal, PA;Stratton, MR;Wooster, R
通讯作者：
Wooster, R
影响因子：
2.7
作者：
Jandke, Anett;Da Costa, Clive;Behrens, Axel
通讯作者：
Behrens, Axel
影响因子：
48
作者：
Buch, T;Heppner, FL;Waisman, A
通讯作者：
Waisman, A
DOI：
10.1186/bcr3593
发表时间：
2014-01-07
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Chang TH;Kunasegaran K;Tarulli GA;De Silva D;Voorhoeve PM;Pietersen AM
通讯作者：
Pietersen AM