Separate coding of different gaze directions in the superior temporal sulcus and inferior parietal lobule.
Separate coding of different gaze directions in the superior temporal sulcus and inferior parietal lobule.
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DOI：
10.1016/j.cub.2006.10.052
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发表时间：
2007-01-09
期刊：
影响因子：
9.2
通讯作者：
Henson, Richard N. A.
中科院分区：
文献类型：
--
作者：
Calder, Andrew J.;Beaver, John D.;Winston, Joel S.;Dolan, Ray J.;Jenkins, Rob;Eger, Evelyn;Henson, Richard N. A.
在猴子的前上级颞沟（STS）的电生理记录已经证明了不同的细胞群响应于直接和转移凝视。人类功能成像已经证明了在凝视处理中的后部STS激活，特别是在对凝视所传达的意图进行编码时，但迄今为止还没有提供不同凝视方向的可分离编码的证据。由于基于组的功能磁共振成像研究的典型空间分辨率（106 -10 mm）超过了对不同面部特征敏感的细胞斑块的大小（猴子为1-4 mm），因此可能需要更敏感的技术。因此，我们使用功能磁共振成像适应，这被认为是提供上级分辨率，调查是否人类前部STS包含不同的注视方向的表示，如非人类灵长类动物的研究所建议的。受试者看到探头的脸凝视左，正前方，或右。在STS前部和顶叶下皮层，适应性凝视使BOLD对左相对于右（和直接）凝视探针的反应减少;适应性凝视使右凝视探针的反应相应减少。与这些发现相一致，在适应的方向上转移的注视被误认为是直接的。我们的研究提供了第一个人类证据，证明左右凝视的神经系统是可分离的。
Electrophysiological recording in the anterior superior temporal sulcus (STS) of monkeys has demonstrated separate cell populations responsive to direct and averted gaze. Human functional imaging has demonstrated posterior STS activation in gaze processing, particularly in coding the intentions conveyed by gaze, but to date has provided no evidence of dissociable coding of different gaze directions. Because the spatial resolution typical of group-based fMRI studies (∼6–10 mm) exceeds the size of cellular patches sensitive to different facial characteristics (1–4 mm in monkeys), a more sensitive technique may be required. We therefore used fMRI adaptation, which is considered to offer superior resolution, to investigate whether the human anterior STS contains representations of different gaze directions, as suggested by non-human primate research. Subjects viewed probe faces gazing left, directly ahead, or right. Adapting to leftward gaze produced a reduction in BOLD response to left relative to right (and direct) gaze probes in the anterior STS and inferior parietal cortex; rightward gaze adaptation produced a corresponding reduction to right gaze probes. Consistent with these findings, averted gaze in the adapted direction was misidentified as direct. Our study provides the first human evidence of dissociable neural systems for left and right gaze.
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