Dual-energy contrast-enhanced breast tomosynthesis: optimization of beam quality for dose and image quality.
Dual-energy contrast-enhanced breast tomosynthesis: optimization of beam quality for dose and image quality.
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DOI：
10.1088/0031-9155/56/19/013
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发表时间：
2011-10-07
影响因子：
3.5
通讯作者：
Saunders RS
中科院分区：
文献类型：
--
作者：
Samei E;Saunders RS
双能对比增强乳腺断层合成是一种很有前景的技术，能够以高分辨率和速度从乳腺获取三维功能信息。为了优化这种新方法，本研究寻找能够在质量检测性能方面最大化图像质量的光束质量。使用快速射线追踪算法对数字断层合成系统进行建模，该算法通过跟踪光子穿过包含碘化病变的体素化乳房解剖模型来创建模拟投影图像。通过加权对数减法过程将单能量图像组合成双能量图像。优化权重因子以最小化解剖噪声，而选择剂量分布以最小化量子噪声。分析双能图像的碘化质量的信号差噪声比（SdNR）。快速射线追踪探索了 523,776 个双能组合，以确定哪种组合能产生最佳质量 SdNR。使用带有硒平板探测器的乳房断层合成系统的蒙特卡罗模型验证了射线追踪结果。我们的体素化乳房模型的投影图像是在恒定的总腺体剂量下获得的。使用加权对数减法组合投影并使用商业重建软件重建。在中央重建切片中测量病变 SdNR。 SdNR 性能在 kVp 和过滤空间上存在显着差异。射线追踪结果表明，使用 49 kVp 的高能钨束和 92.5 μm 的铜过滤以及 49 kVp 的低能钨束和 95 μm 的锡过滤，使 SdNR 的质量最大化。这一结果与蒙特卡罗的研究结果一致。这种乳房X线照相技术导致投影中的质量SdNR为0.92±0.03，重建切片中的质量SdNR为3.68±0.19。这些值明显高于未优化技术的值。我们的研究结果表明，双能乳房断层合成可以在 49 kVp 下使用替代的铜和锡滤波器进行最佳执行，并在加权减法后进行重建。在双能对比增强乳房断层合成中，最佳技术可在结构化乳房背景下提供最佳的碘可见度。
Dual-energy contrast-enhanced breast tomosynthesis is a promising technique to obtain three-dimensional functional information from the breast with high resolution and speed. To optimize this new method, this study searched for the beam quality that maximized image quality in terms of mass detection performance. A digital tomosynthesis system was modeled using a fast ray-tracing algorithm, which created simulated projection images by tracking photons through a voxelized anatomical breast phantom containing iodinated lesions. The single-energy images were combined into dual-energy images through a weighted log subtraction process. The weighting factor was optimized to minimize anatomical noise, while the dose distribution was chosen to minimize quantum noise. The dual-energy images were analyzed for the signal difference to noise ratio (SdNR) of iodinated masses. The fast ray-tracing explored 523,776 dual-energy combinations to identify which yields optimum mass SdNR. The ray-tracing results were verified using a Monte Carlo model for a breast tomosynthesis system with a selenium-based flat-panel detector. The projection images from our voxelized breast phantom were obtained at a constant total glandular dose. The projections were combined using weighted log subtraction and reconstructed using commercial reconstruction software. The lesion SdNR was measured in the central reconstructed slice. The SdNR performance varied markedly across the kVp and filtration space. Ray-tracing results indicated that the mass SdNR was maximized with a high-energy tungsten beam at 49 kVp with 92.5 μm of copper filtration and a low-energy tungsten beam at 49 kVp with 95 μm of tin filtration. This result was consistent with Monte Carlo findings. This mammographic technique led to a mass SdNR of 0.92 ± 0.03 in the projections and 3.68 ± 0.19 in the reconstructed slices. These values were markedly higher than those for non-optimized techniques. Our findings indicate that dual-energy breast tomosynthesis can be performed optimally at 49 kVp with alternative copper and tin filters, with reconstruction following weighted subtraction. The optimum technique provides best visibility of iodine against structured breast background in dual-energy contrast-enhanced breast tomosynthesis.
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