Optimizing Multiscale Entropy Approach for Rotor Core Identification using Simulated Intracardiac Electrograms

Optimizing Multiscale Entropy Approach for Rotor Core Identification using Simulated Intracardiac Electrograms
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使用模拟心内电图优化转子芯识别的多尺度熵方法

DOI:
10.1109/embc44109.2020.9175773
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发表时间:
2020
期刊:
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:414-417.
影响因子:
--
通讯作者:
Tolkacheva, Elena G.
Tolkacheva, Elena G.
中科院分区:
--
文献类型:
--
作者:
Ravikumar, Vasanth;Tolkacheva, Elena G.

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心房纤颤(AF)是最常见的持续性心律失常,是许多致命性心脏病的前兆。导管消融术是一种微创治疗,与持续性AF患者的成功率有限相关。转子被认为可以维持AF,转子的核心被认为是消融的稳健目标。最近,多尺度熵(MSE)被提出来识别离体兔心脏转子的核心。然而,MSE技术是敏感的内部参数,如比例因子和模板的尺寸,这可能会导致不精确的熵测量的估计。本研究的目的是优化MSE方法,以提高其准确性和灵敏度,在转子核心识别使用模拟EGMs从人类心房模型。具体来说,我们已经确定了有效的转子铁芯识别所需的最佳时间比例因子(τopt)和最佳模板尺寸(Topt)。使用收敛图,τ opt被识别为10,并且Topt(~20 ms)在不同采样率下保持相同,这表明优化的MSE将有效地识别转子的核心,而不管信号采集系统如何。
Atrial Fibrillation (AF) is most common sustained cardiac arrhythmia and a precursor to many fatal cardiac conditions. Catheter ablation, which is a minimally invasive treatment, is associated with limited success rates in patients with persistent AF. Rotors are believed to maintain AF and core of rotors are considered to be robust targets for ablation. Recently, multiscale entropy (MSE) was proposed to identify the core of rotors in ex-vivo rabbit hearts. However, MSE technique is sensitive to intrinsic parameters, such as scale factor and template dimension, that may lead to an imprecise estimation of entropy measures. The purpose of this research is optimize MSE approach to improve its accuracy and sensitivity in rotor core identification using simulated EGMs from human atrial model. Specifically, we have identified the optimal time scale factor (τopt) and optimal template dimension (Topt) that are needed for efficient rotor core identification. The τoptwas identified to be 10, using a convergence graph, and the Topt(~20 ms) remained the same at different sampling rates, indicating that optimized MSE will be efficient in identifying core of the rotor irrespective of the signal acquisition system.
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