Advances in stroke therapy.
Advances in stroke therapy.
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DOI：
10.1007/s13346-011-0046-y
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发表时间：
2011-12-01
影响因子：
5.4
通讯作者：
Labhasetwar, Vinod
中科院分区：
文献类型：
--
作者：
Jaffer, Hayder;Morris, Viola B.;Stewart, Desiree;Labhasetwar, Vinod
关键词：
Stroke is a leading cause of death, long-term disability, and socioeconomic costs, highlighting the urgent need for more effective treatments. Intravenous administration of tissue plasminogen activator (t-PA) is the only FDA-approved therapy to re-establish cerebral blood flow. However, because of increased risk of hemorrhage beyond 3 h post stroke, few stroke patients (1–2%) benefit from t-PA; t-PA, which has neurotoxic effects, can also aggravate the extent of reperfusion injury by increasing blood-brain barrier permeability. An alternative strategy is needed to extend the window of intervention, minimize damage from reperfusion injury, and promote brain repair leading to neurological recovery. Reactive oxygen species (ROS), generated soon after ischemia and during reperfusion and thereafter, are considered the main mediators of ischemic injury. Antioxidant enzymes such as catalase, superoxide dismutase, etc. can neutralize ROS-mediated injury but their effective delivery to the brain remains a challenge. In this article, we review various therapeutic approaches including surgical interventions, and discuss the potential of nanoparticle-mediated delivery of antioxidants for stroke therapy.
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DOI：
10.1097/00004647-199803000-00002
发表时间：
1998-03-01
影响因子：
6.3
作者：
Endres, H;Namura, S;Moskowitz, MA
通讯作者：
Moskowitz, MA
影响因子：
4.2
作者：
Goto, Hisaharu;Fujisawa, Hirosuke;Suzuki, Michiyasu
通讯作者：
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影响因子：
15.9
作者：
Cheng, Y;Deshmukh, M;Holtzman, DM
通讯作者：
Holtzman, DM
影响因子：
2.1
作者：
FORSMAN, M;FLEISCHER, JE;MICHENFELDER, JD
通讯作者：
MICHENFELDER, JD
影响因子：
8.3
作者：
Albers, Gregory W.;Goldstein, Larry B.;Saver, Jeffrey L.
通讯作者：
Saver, Jeffrey L.