Cortical pathology in multiple sclerosis detected by the T1/T2-weighted ratio from routine magnetic resonance imaging.
Cortical pathology in multiple sclerosis detected by the T1/T2-weighted ratio from routine magnetic resonance imaging.
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DOI：
10.1002/ana.25020
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发表时间：
2017-10
影响因子：
11.2
通讯作者：
Mühlau M
中科院分区：
文献类型：
--
作者：
Righart R;Biberacher V;Jonkman LE;Klaver R;Schmidt P;Buck D;Berthele A;Kirschke JS;Zimmer C;Hemmer B;Geurts JJG;Mühlau M
在多发性硬化症中，神经病理学研究表明大脑皮层发生了广泛的变化。体内成像至关重要，因为大多数测量的组织病理学底物都是未知的。使用一种新型磁共振成像分析技术，基于 T1 和 T2 加权信号强度的比率，我们研究了一大群多发性硬化症早期患者的大脑皮层。共有 168 名临床孤立综合征或复发缓解型多发性硬化症患者（扩展残疾状态量表：中位数 = 1，范围 = 0–3.5）和 80 名年龄和性别匹配的健康对照者进行了研究。我们还通过结合 9 名多发性硬化症脑供体的尸检成像和组织病理学来寻找 T1/T2 加权比的组织病理学底物。患者顶叶和枕叶区域的 T1/T2 加权比值较低。 4 个最重要的簇出现在内侧枕叶和后扣带皮层（左、右各一个）。后扣带回 T1/T2 加权比的下降与注意力表现有关。对死后成像的 T1/T2 加权比值的分析发现与树突密度有很强的相关性，但与包括髓磷脂在内的其他参数均没有相关性。 T1/T2 加权比在多发性硬化症的早期阶段普遍下降，后部区域占优势，并且对注意力表现有贡献；它似乎反映了树突病理学。由于该方法广泛可用并适用于现有的临床扫描，我们相信它是研究和监测多发性硬化症皮质病理学或治疗效果的有前途的候选者。安·尼罗尔 2017；82：519–529
In multiple sclerosis, neuropathological studies have shown widespread changes in the cerebral cortex. In vivo imaging is critical, because the histopathological substrate of most measurements is unknown. Using a novel magnetic resonance imaging analysis technique, based on the ratio of T1‐ and T2‐weighted signal intensities, we studied the cerebral cortex of a large cohort of patients in early stages of multiple sclerosis. A total of 168 patients with clinically isolated syndrome or relapsing–remitting multiple sclerosis (Expanded Disability Status Scale: median = 1, range = 0–3.5) and 80 age‐ and sex‐matched healthy controls were investigated. We also searched for the histopathological substrate of the T1/T2‐weighted ratio by combining postmortem imaging and histopathology in 9 multiple sclerosis brain donors. Patients showed lower T1/T2‐weighted ratio values in parietal and occipital areas. The 4 most significant clusters appeared in the medial occipital and posterior cingulate cortex (each left and right). The decrease of the T1/T2‐weighted ratio in the posterior cingulate was related to performance in attention. Analysis of the T1/T2‐weighted ratio values of postmortem imaging yielded a strong correlation with dendrite density but none of the other parameters including myelin. The T1/T2‐weighted ratio decreases in early stages of multiple sclerosis in a widespread manner, with a preponderance of posterior areas and with a contribution to attentional performance; it seems to reflect dendrite pathology. As the method is broadly available and applicable to available clinical scans, we believe that it is a promising candidate for studying and monitoring cortical pathology or therapeutic effects in multiple sclerosis. Ann Neurol 2017;82:519–529
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DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
--
作者：
Bo, Lars;Geurts, Jeroen J. G.;Barkhof, Frederik
通讯作者：
Barkhof, Frederik
影响因子：
3.5
作者：
Molet J;Maras PM;Kinney-Lang E;Harris NG;Rashid F;Ivy AS;Solodkin A;Obenaus A;Baram TZ
通讯作者：
Baram TZ
影响因子：
9.9
作者：
Chen, Jacqueline Tien-Hsiang;Easley, Kathryn;Trapp, Bruce D.
通讯作者：
Trapp, Bruce D.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI