Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.
Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.
复制标题
DOI：
10.1371/journal.pone.0097248
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Baker MS
中科院分区：
文献类型：
--
作者：
Ahn SB;Mohamedali A;Chan C;Fletcher J;Kwun SY;Clarke C;Dent OF;Chapuis PH;Nice E;Baker MS
整合素ανβ6在一系列人类癌症中高度表达，并且经常与患者存活相关。本研究检查了ανβ6表达与B期和C期直肠癌中患者临床病理学特征（包括总生存期）之间的相关性。使用免疫组织化学在362个B或C期直肠癌组织样品中测量肿瘤中心区域、侵袭性肿瘤前部和邻近非肿瘤性粘膜处的ανβ6的表达。发现ανβ6的分布在侵袭性前沿显著高于肿瘤的中心区域（p<0.001）或邻近的非肿瘤性粘膜（p<0.001），表明ανβ6在肿瘤细胞侵袭中起作用。然而，整联蛋白ανβ6表达与临床病理学特征或总生存期无关，表明其不是区分B期或C期直肠癌的独立预后标志物。之前的α v β6研究表明α v β6的表达涉及肿瘤进展的早期阶段（即A/B阶段），而不是后期阶段（即C/D阶段）。然而，我们的研究已经揭示，在直肠癌中，ανβ6表达在B期和C期之间不增加，但可能发生得更早，即在B期癌症之前或期间。
Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting ανβ6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer.
登录
查看更多内容
影响因子：
3.2
作者：
Ahmed, N;Riley, C;Baker, MS
通讯作者：
Baker, MS
影响因子：
9
作者：
Darakhshan, Amir;Lin, Betty P. F. C.;Bokey, Les
通讯作者：
Bokey, Les
DOI：
10.1111/j.1440-1746.1991.tb00867.x
发表时间：
1991-07-01
影响因子：
4.1
作者：
FIELDING, LP;ARSENAULT, PA;NEWLAND, RC
通讯作者：
NEWLAND, RC
影响因子：
3.4
作者：
Keshava, A.;Chapuis, P. H.;Dent, O. F.
通讯作者：
Dent, O. F.
影响因子：
4.8
作者：
Morgan, MR;Thomas, GJ;Marshall, JF
通讯作者：
Marshall, JF