Aberrant regulation of autophagy in mammalian diseases
Aberrant regulation of autophagy in mammalian diseases
复制标题
哺乳动物疾病中自噬的异常调节
DOI：
10.1098/rsbl.2017.0540
复制
发表时间：
2018
期刊：
影响因子：
3.3
通讯作者：
Zhou Jun
中科院分区：
文献类型：
--
作者：
Xie Wei;Zhou Jun
自噬是真核细胞中一种主要的细胞代谢途径，它促进了一部分长寿命蛋白和细胞质细胞器的降解。除了维持细胞更新的正常生理状态外，该途径在维持细胞自身的细胞稳态方面起着至关重要的作用。许多应激因素，如饥饿、缺血和氧化应激都可以诱导自噬。除了其生理作用外，自噬还发生在各种病理过程中，包括肿瘤进展，代谢紊乱，神经退行性疾病和肺部疾病。近年来，越来越多的证据表明，自噬在哺乳动物疾病的发展中也起着关键作用，这一功能已经引起了大量的关注和研究。深入了解自噬在病理环境中发挥的分子作用对于哺乳动物疾病的诊断和治疗至关重要，并将有助于寻找治疗药物干预的新靶点。在这里，我们提供了一个综合性的审查，最近的研究涉及自噬功能障碍的哺乳动物疾病的进展，并总结研究表明，自噬参与的分子途径可以作为潜在的治疗目标。
Autophagy is a major cellular metabolic pathway that facilitates degradation of a subset of long-lived proteins and cytoplasmic organelles in eukaryotic cells. This pathway plays a vital role in preserving the cellular homeostasis of the cells themselves, in addition to maintaining the normal physiological state of cell renewal. Many stressors, such as starvation, ischaemia and oxidative stress can induce autophagy. In addition to its physiological roles, autophagy also occurs in a wide variety of pathological processes, including tumour progression, metabolic disorders, and neurodegenerative and lung diseases. In recent years, a growing body of evidence has shown that autophagy also plays a key role in the development of mammalian diseases, a function that has garnered substantial attention and study. An in-depth understanding of the molecular role that autophagy plays in pathological settings is vital for both the diagnosis and treatment of mammalian diseases and will aid in the search for novel targets for therapeutic drug intervention. Here, we provide an integrated review of recent studies implicating autophagy dysfunction in the progression of mammalian disorders and summarize research suggesting that the molecular pathways involved in autophagy could serve as potential therapeutic targets.
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