Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery.
Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery.
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DOI：
10.1016/j.isci.2021.102305
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发表时间：
2021-04-23
期刊：
影响因子：
5.8
通讯作者：
Kurihara H
中科院分区：
文献类型：
--
作者：
Maruyama K;Naemura K;Arima Y;Uchijima Y;Nagao H;Yoshihara K;Singh MK;Uemura A;Matsuzaki F;Yoshida Y;Kurihara Y;Miyagawa-Tomita S;Kurihara H
心脏周围的血管和淋巴管是通过不同来源的细胞经过精心安排的过程发展起来的。特别是，流出道周围的细胞构成了原始的瞬时血管系统，称为主动脉心外膜下血管，对冠状动脉干和心脏淋巴管的建立至关重要。在这里，我们揭示了心外膜和心包来源的Semaphorin 3E(Sema3E)及其受体PlexinD1在冠状动脉干和心脏淋巴管的发育中发挥作用。体外分析表明，Sema3E可能会划定区域，以排斥表达PlexinD1的淋巴管内皮细胞，导致适当的冠状动脉和淋巴管形成。此外，失活Sema3E-PlexinD1信号通过增加成年小鼠心肌梗死模型中反应性淋巴管的生成，改善了心功能的恢复。这些发现可能导致针对冠状动脉疾病的Sema3E-PlexinD1信号转导的治疗策略。Sema3E-PlexinD1信号调节冠状动脉和心脏淋巴管的发育Sema3E划定区域以排斥表达PlexinD1的淋巴管内皮细胞抑制Sema3E-PlexinD1信号促进心肌损伤后的恢复
Blood and lymphatic vessels surrounding the heart develop through orchestrated processes from cells of different origins. In particular, cells around the outflow tract which constitute a primordial transient vasculature, referred to as aortic subepicardial vessels, are crucial for the establishment of coronary artery stems and cardiac lymphatic vessels. Here, we revealed that the epicardium and pericardium-derived Semaphorin 3E (Sema3E) and its receptor, PlexinD1, play a role in the development of the coronary stem, as well as cardiac lymphatic vessels. In vitro analyses demonstrated that Sema3E may demarcate areas to repel PlexinD1-expressing lymphatic endothelial cells, resulting in proper coronary and lymphatic vessel formation. Furthermore, inactivation of Sema3E-PlexinD1 signaling improved the recovery of cardiac function by increasing reactive lymphangiogenesis in an adult mouse model of myocardial infarction. These findings may lead to therapeutic strategies that target Sema3E-PlexinD1 signaling in coronary artery diseases. Sema3E-PlexinD1 signaling regulates coronary and cardiac lymphatic vessel development Sema3E demarcate areas to repel PlexinD1-expressing lymphatic endothelial cells Inhibition of Sema3E-PlexinD1 signaling improves the recovery after myocardial injury Biological Sciences; Cell Biology; Developmental Biology
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