Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology.
Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology.
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DOI：
10.1016/j.neubiorev.2008.08.007
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发表时间：
2009-03
影响因子：
8.2
通讯作者：
Lucki, Irwin
中科院分区：
文献类型：
--
作者：
Balu, Darrick T.;Lucki, Irwin
关键词：
现在已经确定，哺乳动物的大脑有能力在成年后产生新的神经元。一个这样的区域，提供适当的环境，以维持祖细胞，并允许神经元的命运决定是位于海马齿状回。本文将详细讨论成年海马神经发生的复杂过程，包括增殖，分化，存活，并纳入神经元网络。这种现象的调节由许多因素，包括神经递质系统，生长因子，旁分泌信号分子，神经肽，转录因子，内源性精神系统，性激素，压力，和其他。本文还对成年海马颗粒细胞在海马电路、动力学和行为学方面的功能意义进行了综述。此外，扰动成人海马神经发生的各种疾病状态，包括抑郁症，精神分裂症，癫痫和糖尿病的病理生理学的相关性进行了检查。最后，这篇综述讨论了使用海马神经发生作为这些疾病的治疗靶点的潜力。
It is now well established that the mammalian brain has the capacity to produce new neurons into adulthood. One such region that provides the proper milieu to sustain progenitor cells and is permissive to neuronal fate determination is located in the dentate gyrus of the hippocampus. This review will discuss in detail the complex process of adult hippocampal neurogenesis, including proliferation, differentiation, survival, and incorporation into neuronal networks. The regulation of this phenomenon by a number of factors is described, including neurotransmitter systems, growth factors, paracrine signaling molecules, neuropeptides, transcription factors, endogenous psychotropic systems, sex hormones, stress, and others. This review also addresses the functional significance of adult born hippocampal granule cells with regard to hippocampal circuitry dynamics and behavior. Furthermore, the relevance of perturbations in adult hippocampal neurogenesis to the pathophysiology of various disease states, including depression, schizophrenia, epilepsy, and diabetes are examined. Finally, this review discusses the potential of using hippocampal neurogenesis as a therapeutic target for these disorders.
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募集在电击性癫痫发作介导的成年大鼠海马神经发生调节中的声音刺猬信号级联。
DOI：
10.1111/j.1460-9568.2005.04317.x
发表时间：
2005-10
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Banerjee SB;Rajendran R;Dias BG;Ladiwala U;Tole S;Vaidya VA
通讯作者：
Vaidya VA
影响因子：
6.1
作者：
Baker, SA;Baker, KA;Hagg, T
通讯作者：
Hagg, T
影响因子：
7.6
作者：
Banasr, M;Hery, M;Daszuta, A
通讯作者：
Daszuta, A
影响因子：
3.5
作者：
Becker, S
通讯作者：
Becker, S
影响因子：
5.3
作者：
Benraiss, A;Chmielnicki, E;Goldman, SA
通讯作者：
Goldman, SA