ENHANCED ELECTRODIFFUSIVE TRANSPORT ACROSS A MUCUS LAYER.
ENHANCED ELECTRODIFFUSIVE TRANSPORT ACROSS A MUCUS LAYER.
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DOI：
10.1137/20m1348327
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发表时间：
2021
影响因子：
1.9
通讯作者：
Keener JP
中科院分区：
文献类型：
--
作者：
Lewis OL;Keener JP
小离子物质通过粘液层的扩散运输是生理学中普遍存在的现象。然而，关于粘液的各种特性（聚合物本身的电荷、离子与粘液的结合亲和力）如何影响小离子可以扩散通过水合粘液凝胶的速率仍然存在一些争论。事实上，甚至不清楚小离子物质是否以与它们在水溶液中明显不同的速率扩散通过粘液凝胶。在这里，我们提出了一个数学描述的运输两种离子物种（氢和氯）通过粘液层的基础上的能斯特-普朗克方程的电扩散。该模型明确说明了氢对粘液物质的结合亲和力，以及在有粘液和无粘液的区域之间的界面处发生的唐南电位。离子种类的稳态通量被量化，因为它们依赖于粘液凝胶的化学性质和浴溶液的组成。我们概述了一种机制，产生增强的扩散通量的氢在整个凝胶区域，并假设这种机制可能是相关的文献中明显矛盾的实验数据。
Diffusive transport of small ionic species through mucus layers is a ubiquitous phenomenon in physiology. However, some debate remains regarding how the various characteristics of mucus (charge of the polymers themselves, binding affinity of ions with mucus) impact the rate at which small ions may diffuse through a hydrated mucus gel. Indeed it is not even clear if small ionic species diffuse through mucus gel at an appreciably different rate than they do in aqueous solution. Here, we present a mathematical description of the transport of two ionic species (hydrogen and chloride) through a mucus layer based on the Nernst-Planck equations of electrodiffusion. The model explicitly accounts for the binding affinity of hydrogen to the mucus material, as well as the Donnan potential that occurs at the interface between regions with and without mucus. Steady state fluxes of ionic species are quantified, as are their dependencies on the chemical properties of the mucus gel and the composition of the bath solution. We outline a mechanism for generating enhanced diffusive flux of hydrogen across the gel region, and hypothesize how this mechanism may be relevant to the apparently contradictory experimental data in the literature.
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影响因子：
4.4
作者：
GRIMSHAW, PE;NUSSBAUM, JH;YARMUSH, ML
通讯作者：
YARMUSH, ML
影响因子：
5.3
作者：
Hong, Wei;Zhao, Xuanhe;Suo, Zhigang
通讯作者：
Suo, Zhigang
影响因子：
--
作者：
JOHANSSON, L;SKANTZE, U;LOFROTH, JE
通讯作者：
LOFROTH, JE
影响因子：
16.1
作者：
Newby JM;Seim I;Lysy M;Ling Y;Huckaby J;Lai SK;Forest MG
通讯作者：
Forest MG
影响因子：
--
作者：
PFEIFFER, CJ
通讯作者：
PFEIFFER, CJ