Timing without coding: How do long non-coding RNAs regulate circadian rhythms?

Timing without coding: How do long non-coding RNAs regulate circadian rhythms?
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DOI:
10.1016/j.semcdb.2021.04.020
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发表时间:
2022-06
影响因子:
7.3
通讯作者:
Kojima S
Kojima S
中科院分区:
生物学2区
文献类型:
--
作者:
Mosig RA;Kojima S

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长链非编码rna (Long non-coding rna, lncRNAs)是一类新的调控rna,在疾病发生和多种生物学过程中发挥重要作用。最近的研究强调了lncrna在生物钟系统中的重要性,并证明lncrna调节哺乳动物的核心时钟基因和核心时钟机制。在这篇综述中,我们概述了我们目前对lncRNAs如何在不编码蛋白质的情况下调节生物钟的理解。我们还对理解lncrna功能的挑战和该领域其他未解决的问题提供了额外的见解。我们没有涵盖其他调控ncrna,尽管它们也起着重要的作用;我们强烈鼓励读者参考关于这个主题的其他优秀评论。
Long non-coding RNAs (lncRNAs) are a new class of regulatory RNAs that play important roles in disease development and a variety of biological processes. Recent studies have underscored the importance of lncRNAs in the circadian clock system and demonstrated that lncRNAs regulate core clock genes and the core clock machinery in mammals. In this review, we provide an overview of our current understanding of how lncRNAs regulate the circadian clock without coding a protein. We also offer additional insights into the challenges in understanding the functions of lncRNAs and other unresolved questions in the field. We do not cover other regulatory ncRNAs even though they also play important roles; readers are highly encouraged to refer to other excellent reviews on this topic.
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