Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder.
Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder.
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DOI：
10.1016/j.jaac.2011.06.011
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发表时间：
2011-09
影响因子：
13.3
通讯作者：
Taylor SF
中科院分区：
文献类型：
--
作者：
Fitzgerald KD;Welsh RC;Stern ER;Angstadt M;Hanna GL;Abelson JL;Taylor SF
Pediatric obsessive-compulsive disorder is characterized by abnormalities of frontal-striatalthalamic circuitry that appear near illness onset and persist over its course. Distinct frontal-striatal-thalamic loops through cortical centers for cognitive control (anterior cingulate cortex) and emotion processing (ventral medial frontal cortex) follow unique maturational trajectories, and altered connectivity within distinct loops may be differentially associated with OCD at specific stages of development. Altered development of striatal and thalamic connectivity to medial frontal cortex was tested in 60 OCD patients compared to 61 healthy controls at child, adolescent and adult stages of development, using resting state functional connectivity MRI. OCD in the youngest patients was associated with reduced connectivity of dorsal striatum and medial dorsal thalamus to rostral and dorsal anterior cingulate cortex, respectively. Increased connectivity of dorsal striatum to ventral medial frontal cortex was observed in patients at all developmental stages. In child patients, reduced connectivity between dorsal striatum and rostral anterior cingulate cortex correlated with OCD severity. Frontal-striatal-thalamic loops involved in cognitive control are hypoconnected in young patients near illness onset, while loops implicated in emotion-processing are hyperconnected throughout the illness.
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