Frontostriatal maturation predicts cognitive control failure to appetitive cues in adolescents.
Frontostriatal maturation predicts cognitive control failure to appetitive cues in adolescents.
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DOI：
10.1162/jocn.2010.21572
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发表时间：
2011-09
影响因子：
3.2
通讯作者：
Casey BJ
中科院分区：
文献类型：
--
作者：
Somerville LH;Hare T;Casey BJ
青少年冒险是一个公共卫生问题，增加了一生中不良结果的可能性。据认为，影响青少年冒险倾向的一个因素是对食欲线索的敏感性增强，相对于不成熟的能力来施加足够的认知控制。我们测试了这一假设的特征腹侧纹状体，背侧纹状体和前额叶皮层区域之间的相互作用，不同的食欲负荷，功能性磁共振成像（fMRI）扫描。儿童，青少年和成人参与者进行了一个去nogo任务与食欲（快乐的脸）和中性线索（平静的脸）。中性线索的冲动控制表现出线性改善与年龄，而青少年表现出非线性减少冲动控制食欲线索。青少年的这种表现下降被腹侧纹状体活动的增强所抵消。前额叶皮质募集与整体准确性相关，并显示出nogo与go试验的线性反应与年龄。连接分析确定了一个腹侧额纹状体电路，包括额下回和背侧纹状体在nogo与go试验。发育性的研究发现，在快乐的nogo与go试验中，青少年相对于儿童和成人有更大的受试者腹背侧纹状体共激活。这些发现暗示夸大腹侧纹状体代表性的食欲线索在青少年相对于中介认知控制反应。连通性和协同活动的数据表明，这些系统在不同的发展水平的背侧纹状体沟通。在这个系统中，有偏见的反应是青少年时期冒险行为加剧的一个可能机制。
Adolescent risk-taking is a public health issue that increases the odds of poor lifetime outcomes. One factor thought to influence adolescents' propensity for risk-taking is an enhanced sensitivity to appetitive cues, relative to an immature capacity to exert sufficient cognitive control. We tested this hypothesis by characterizing interactions among ventral striatal, dorsal striatal and prefrontal cortical regions with varying appetitive load using functional magnetic resonance imaging (fMRI) scanning. Child, teen, and adult participants performed a go nogo task with appetitive (happy faces) and neutral cues (calm faces). Impulse control to neutral cues showed linear improvement with age, whereas teens showed a nonlinear reduction in impulse control to appetitive cues. This performance decrement in teens was paralleled by enhanced activity in the ventral striatum. Prefrontal cortical recruitment correlated with overall accuracy and showed a linear response with age for nogo versus go trials. Connectivity analyses identified a ventral frontostriatal circuit including the inferior frontal gyrus and dorsal striatum during nogo versus go trials. Examining recruitment developmentally showed that teens had greater between-subjects ventral-dorsal striatal coactivation relative to children and adults for happy nogo versus go trials. These findings implicate exaggerated ventral striatal representation of appetitive cues in adolescents relative to an intermediary cognitive control response. Connectivity and coactivity data suggest these systems communicate at the level of the dorsal striatum differentially across development. Biased responding in this system is one possible mechanism underlying heightened risk-taking during adolescence.
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影响因子：
3.7
作者：
Durston, S;Davidson, MC;Casey, BJ
通讯作者：
Casey, BJ
影响因子：
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作者：
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DOI：
10.1097/00004583-199703000-00016
发表时间：
1997-03-01
影响因子：
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作者：
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作者：
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影响因子：
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作者：
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通讯作者：
Woolard, Jennifer