The anxiolytic effects of a Valerian extract is based on valerenic acid.
The anxiolytic effects of a Valerian extract is based on valerenic acid.
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DOI：
10.1186/1472-6882-14-267
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发表时间：
2014-07-28
影响因子：
--
通讯作者：
Brattström A
中科院分区：
文献类型：
--
作者：
Becker A;Felgentreff F;Schröder H;Meier B;Brattström A
缬草常用于治疗失眠和焦虑。缬草提取物变构调节GABA-A受体，诱导抗焦虑活性。该活性与戊酸密切相关。本实验研究乙氧基戊酸是否会干扰戊酸的抗焦虑作用。用雄性CD-1小鼠在口服试验物质后的升高加迷宫试验中测量情境焦虑。此外，还测量了体核温度。3H-GABA结合实验采用雄性RjHan:WI大鼠额叶皮质解剖组织。统计评价采用非参数Kruskal-Wallies h检验，然后采用双尾Mann-Whitney u检验。乙氧基戊酸的加入消除了戊酸的抗焦虑作用。对身体核心温度没有影响。此外，缬草提取物对苯二氮卓类药物的结合位点没有任何亲和力。所观察到的缬草提取物的抗焦虑作用的决定化合物是其戊酸含量。
Valerian is commonly used for the treatment of insomnia and anxiety. Valerian extracts allosterically modulate GABA-A receptors and induced an anxiolytic activity. This activity is closely related to valerenic acid. In the present experiments it was investigated whether acetoxy valerenic acid may interfere with the anxiolytic action of valerenic acid. Situational anxiety was measured using male CD-1 mice in the elevated plus maze test after oral administration of the test substances. In addition the body core temperature was measured. For the 3H-GABA binding assay dissected tissue from frontal cortex of male RjHan:WI rats were used. Statistical evaluation was performed by means of the non-parametric Kruskal-Wallies H-test, followed by the two-tailed Mann–Whitney U-test. Adding of acetoxy valerenic acid abolished the anxiolytic action of valerenic acid. There was no effect on body core temperature. Moreover, the valerian extract did not show any affinity to benzodiazepine binding sites. The determining compound for the observed anxiolytic effect of the valerian extract is its content of valerenic acid.
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影响因子：
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