Serum Biomarkers in a Radiological Pattern of Non-Fibrotic Hypersensitivity Pneumonitis: Implications for Mechanistic Difference and Differential Diagnosis.
Serum Biomarkers in a Radiological Pattern of Non-Fibrotic Hypersensitivity Pneumonitis: Implications for Mechanistic Difference and Differential Diagnosis.
复制标题
DOI：
10.3390/diseases10030036
复制
发表时间：
2022-06-27
期刊：
影响因子：
3.7
通讯作者：
Nakamura, Yukihiro
中科院分区：
文献类型：
--
作者：
Takimoto, Takayuki;Nakamura, Yukihiro
关键词：
过敏性肺炎（HP）是由反复暴露于环境因子引起的免疫介导反应的结果。最近，HP诊断的临床实践指南的发表增加了人们对HP的兴趣。另一方面，最近出现了针对各种疾病的新疗法，药物相关性肺炎（DRP）的管理变得越来越重要。在DRP中，HP型（DRP-HP）表现为小的、界限不清的小叶中心结节，伴或不伴广泛的磨玻璃样混浊区或小叶区衰减和血管减少。无论吸入（非纤维化HP）还是静脉给药（DRP-HP），均可诱导类似的非纤维化HP的放射学模式。然而，尽管两种情况下肺部病变的分布略有不同，但它们的差异尚未得到很好的描述。在这篇综述中，我们着眼于肺上皮细胞的血清生物标志物，以探讨DRP-HP和非纤维化HP（普通HP）之间的差异。与普通hp相比，DRP-HP患者血清Krebs von den Lungen 6 （KL-6）水平可能相对较低（偶尔正常），暗示存在机制差异。KL-6可用于区分DRP和非纤维化HP（普通型）。
Hypersensitivity pneumonitis (HP) is a consequence of immune-mediated reactions caused by recurrent exposure to environmental agents. Recently, clinical practice guidelines for the diagnosis of HP were published and increased interest in HP. On the other hand, novel therapies have recently emerged for various diseases, and the management of drug-related pneumonitis (DRP) has become increasingly important. Among DRP, the HP pattern (DRP-HP) shows small, poorly defined centrilobular nodules with or without widespread areas of ground-glass opacity or lobular areas of decreased attenuation and vascularity. A similar radiological pattern of non-fibrotic HP can be induced, irrespective of inhalation (non-fibrotic HP) or intravenous administration (DRP-HP). However, their difference has not been well described, although the distribution of lesions in the lungs was slightly different between these two conditions. In this review, we focus on serum biomarkers of lung epithelial cells in order to investigate the difference between DRP-HP and non-fibrotic HP (common-HP). Serum levels of Krebs von den Lungen 6 (KL-6) might be relatively lower (occasionally normal) in DRP-HP than in common-HP, implying a mechanistic difference. KL-6 could be useful in discriminating between DRP and non-fibrotic HP (common type).
登录
查看更多内容
影响因子：
5.8
作者：
Kakugawa T;Yokota S;Ishimatsu Y;Hayashi T;Nakashima S;Hara S;Sakamoto N;Matsuoka Y;Kubota H;Mine M;Mukae H;Nagata K;Kohno S
通讯作者：
Kohno S
DOI：
10.1183/16000617.0012-2019
发表时间：
2019-12-31
期刊：
European respiratory review : an official journal of the European Respiratory Society
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.6
作者：
KOHNO, N;KYOIZUMI, S;AKIYAMA, M
通讯作者：
AKIYAMA, M
影响因子：
24.3
作者：
Imokawa, S;Colby, TV;Helmers, RA
通讯作者：
Helmers, RA
影响因子：
10
作者：
Ohnishi, H;Yokoyama, A;Kohno, N
通讯作者：
Kohno, N